C(sp3)-H　activation　of　alcohols　enables　creating　new　C　&　horbar;C　bond　while　keeping　hydroxyl　group　in　a　step　and　atom　economic　manner.　Here,　we　disclose　a　protocol　of　coupling　alcohols　with　alkenes　for　C(sp3)-C(sp3)　bond　formation　via　heterogeneous　photocatalysis　in　flow.　This　protocol　functions　well　with　a　broad　scope　of　alcohols　(primary　and　secondary　alcohols)　and　alkenes　with　moderate　to　good　yields.　The　heterogeneous　photocatalysis　in　flow　enables　current　methodology　to　be　conducted　even　on　gram　scale,　exhibiting　great　potential　for　industrial　applications.　Cleavage　of　alpha-C(sp3)-H　of　alcohol　is　induced　by　S　center　dot　species　on　the　surface　of　ZnIn2S4　via　hydrogen　atom　transfer　(HAT),　and　this　step　was　found　to　be　involved　in　the　rate-determining　step.