Background　Diet,　lifestyle,　and　oxidative　stress　have　been　linked　to　female　infertility,　with　the　Oxidative　Balance　Score　(OBS)　serving　as　a　comprehensive　indicator　of　an　individual＇s　oxidative　and　antioxidant　status.　This　study　aims　to　investigate　the　correlation　between　OBS　and　female　infertility.Methods　The　National　Health　and　Nutrition　Examination　Survey　(NHANES)　from　2013　to　2020　were　utilized.　Weighted　multivariate　regression　analyses　and　restricted　cubic　splines　(RCS)　were　employed　to　analysis.　Additionally,　subgroup　analyses　and　multiple　imputat6ions　(MI)　were　carried　out　as　sensitivity　analyses　to　ensure　the　strength　and　reliability　of　the　findings.Results　A　total　of　3,905　individuals　were　involved　in　the　study,　the　prevalence　of　female　infertility　was　11.96%.　Individuals　with　infertility　exhibited　significantly　lower　OBS　compared　to　those　with　normal　fertility　(19.74　+/-　0.37　vs.　21.42　+/-　0.20).　The　OBS　dietary　and　lifestyle　components　also　had　lower　scores,　with　averages　of　15.98　+/-　0.33　vs.　17.12　+/-　0.18　and　3.76　+/-　0.11　vs.　4.29　+/-　0.05,　respectively.　Weighted　logistic　regression　results　revealed　that　a　one-point　increase　in　OBS　score　was　associated　with　a　3%　decrease　in　infertility　risk　(Odds　Ratio　(OR)　0.97,　95%　Confidence　Interval　(CI):　0.95,　0.99).　Similarly,　a　one-point　increase　in　OBS　lifestyle　score　was　linked　to　a　15%　decrease　in　infertility　risk　(OR:　0.85,　95%　CI:　0.75,　0.96),　and　a　one-point　increase　in　OBS　dietary　score　was　associated　with　a　2%　decrease　in　infertility　risk　(OR:　0.98,　95%　CI:　0.96,　0.99).　Subgroup　analyses　revealed　that　individuals　with　no　prior　history　of　pregnancy　benefited　more　from　OBS　and　OBS　lifestyle　in　terms　of　infertility　risk　reduction　compared　to　those　with　a　history　of　pregnancy.Conclusion　OBS　is　found　to　have　a　negative　correlation　with　infertility,　particularly　in　cases　of　primary　infertility.　The　results　of　this　study　indicate　that　adopting　an　antioxidant-rich　diet　and　lifestyle　could　potentially　lower　the　risk　of　infertility.