Talc　is　a　layered　silicate　mineral　with　pronounced　crystal　anisotropy,　consisting　of　a　basal　(001)　surface　and　an　edge　(100)　surface,　which　complicates　its　separation　from　valuable　minerals.　In　this　study,　tannic　acid　(TA)　was　used　as　a　depressant,　and　its　adsorption　behaviors　on　the　two　representative　surfaces　of　talc-silica　(basal　plane　surface)　and　magnesium　silicate　(edge　surface)-were　systematically　investigated　using　experimental　methods　and　molecular　simulations.　TA　addition　reduced　the　contact　angles　of　the　talc　basal　and　edge　surfaces　by　30.5　degrees　and　22.7　degrees,　respectively,　indicating　enhanced　hydrophilicity.　ToF-SIMS　analysis　revealed　that　TA　physically　adsorbs　onto　the　silica　surface,　while　both　physical　and　chemical　interactions　occur　on　the　magnesium　silicate　surface.　AFM　showed　lumpy　adsorbate　on　the　silica　surface　and　point-like　adsorbate　on　the　magnesium　silicate　surface,　with　a　greater　roughness　change　observed　for　the　former.　QCM-D　measurements　confirmed　that　TA　formed　a　multilayer　flexible　adsorbate　on　the　silica　surface　and　a　dense,　rigid　monolayer　on　the　magnesium　silicate　surface.　Molecular　dynamics　simulations　further　revealed　that　van　der　Waals　interactions　dominated　TA　adsorption　on　the　(001)　surface,　while　electrostatic　interactions　prevailed　on　the　(100)　surface.　These　findings　provide　insight　into　the　selective　depression　mechanism　of　talc　and　offer　guidance　for　the　depression　of　other　layered　silicate　minerals.