• Complex
  • Title
  • Keyword
  • Abstract
  • Scholars
  • Journal
  • ISSN
  • Conference
成果搜索

author:

Lu, Tong-Yu (Lu, Tong-Yu.) [1] | Lin, Yueqiong (Lin, Yueqiong.) [2] | Zhong, Junjiang (Zhong, Junjiang.) [3]

Indexed by:

Scopus SCIE

Abstract:

The response variable in clinical studies is frequently ordinal. In the comparison of treatment efficacies, the latent Weibull model has been shown to be a powerful tool that is appropriate for testing even when the data are highly skewed, a condition under which the traditional proportional odds model may be unsuitable owing to the possible inflation of the type-I error rate. A response-adaptive treatment randomization scheme based on the latent Weibull model has recently been proposed to allow more patients to receive the better treatment while maintaining competitive test power. Nevertheless, the proposed procedure has been restricted to the comparison of two treatments. This paper generalizes the aforementioned idea to include trials with multiple treatments. Statistical procedures for pairwise comparisons and multiple comparisons with a control are discussed. Furthermore, a simulation study is performed to illustrate the superiority of the proposed method. The practical benefits of the suggested procedures are demonstrated through the redesign of two clinical trials.

Keyword:

Allocation target Latent Weibull model Multiple comparisons Ordinal responses Response-adaptive treatment allocation

Community:

  • [ 1 ] [Lu, Tong-Yu]China Jiliang Univ, Coll Econ & Management, Hangzhou, Peoples R China
  • [ 2 ] [Lin, Yueqiong]Fuzhou Univ, Sch Math & Stat, Fuzhou, Peoples R China
  • [ 3 ] [Zhong, Junjiang]Xiamen Univ Technol, Sch Math & Stat, Xiamen, Peoples R China

Reprint 's Address:

  • [Lin, Yueqiong]Fuzhou Univ, Sch Math & Stat, Fuzhou, Peoples R China

Show more details

Related Keywords:

Source :

JOURNAL OF THE KOREAN STATISTICAL SOCIETY

ISSN: 1226-3192

Year: 2025

0 . 6 0 0

JCR@2023

Cited Count:

WoS CC Cited Count:

SCOPUS Cited Count:

ESI Highly Cited Papers on the List: 0 Unfold All

WanFang Cited Count:

Chinese Cited Count:

30 Days PV: 0

Online/Total:458/11096399
Address:FZU Library(No.2 Xuyuan Road, Fuzhou, Fujian, PRC Post Code:350116) Contact Us:0591-22865326
Copyright:FZU Library Technical Support:Beijing Aegean Software Co., Ltd. 闽ICP备05005463号-1