It　is　highly　desirable　but　still　remains　challenging　to　develop　high-performance　hydrogels　with　satisfactory　mechanical　properties　for　tissue　engineering.　Here,　anisotropic　yet　transparent　hydrogels　(AHs)　are　prepared　for　tendon　repair　via　a　facile　“poor　solvent　evaporation　assisted　hot-stretching”　strategy.　AHs　have　great　mechanical　properties　with　tensile　strength,　toughness,　and　fracture　energy　as　high　as　33.14　±　2.05 MPa,　44.1　±　3.5 MJ m−3,　and　106.18　±　7.2 kJ m−2,　respectively.　Especially,　AHs　show　unique　flaw-insensitive　characteristics,　and　cracks　can　only　deflect　along　the　fiber　alignment　direction　rather　than　propagate　transverse　to　this　direction,　showing　an　interesting　self-protection　function.　The　high　strength,　toughness,　and　fatigue　resistance　originate　from　the　hierarchal　structure　of　AHs,　i.e.,　the　densified　polymeric　network　comprising　fiber　bundles　and　nanofibrils　with　aligned　macromolecular　chains,　crystalline　domains,　and　intermolecular　hydrogen　bonds.　AHs　with　superior　biocompatibility　and　swelling　resistance　can　be　used　to　repair　rat　tendons,　and　implantation　of　AHs　can　promote　collagen　regeneration　for　the　tendon　repair.　This　study　provides　a　new　method　to　fabricate　strong　and　anti-fatigue　hydrogels　as　a　new　class　of　promising　materials　for　soft　tissues.　©　2025　The　Author(s).　Advanced　Science　published　by　Wiley-VCH　GmbH.