α-methylstyrene-maleic　anhydride　crosslinked　copolymer　microspheres(PAMSMs)　were　prepared　via　self-stable　precipitation　polymerization,　and　then　β-cyclodextrin(β-CD)　functionalized　microspheres　PAMSMs-CD　were　obtained　by　immobilizing　β-CD　on　the　PAMSMs.　Carboxyl-functionalized　crosslinked　copolymer　microspheres　of　H-PAMSMs-CD　were　achieved　by　the　hydrolysis　of　PAMSMs-CD.　The　morphology　and　surface　functional　groups　of　the　microspheres　were　char⁃　acterized.　H-PAMSMs-CD　microspheres　were　used　as　adsorbents　to　remove　methylene　blue(MB)　from　water.　The　effects　of　adsorbent　dosage,　adsorption　time,　initial　concentration　of　MB,　temperature,　pH,　and　other　factors　on　the　adsorption　efficiency　of　H-PAMSMs-CD　microspheres　for　MB　were　studied.　SEM　analysis　showed　that　H-PAMSMs-CD　with　spherical　morphology　and　narrow　size　distribution　were　obtained.　It　was　found　that　microspheres　had　good　removal　ability　on　MB.　The　maximum　adsorption　capacity　of　H-PAMSMs-CD　for　MB　was　up　to　381　mg/g　when　the　initial　concentration　of　MB　was　120　mg/L,　the　dosage　of　adsorbent　was　0.25　g/L,　pH　of　solution　was　7,　the　adsorption　temperature　was　40　℃,　and　the　reaction　time　was　4　h.　The　adsorption　process　of　H-PAMSMs-CD　on　MB　could　be　better　described　by　the　Langmuir　model　and　quasi　second-order　kinetic　model,　which　was　a　spontaneous　endothermic　process.　Furthermore,　the　removal　rate　of　MB　by　H-PAMSMs-CD　could　be　maintained　more　than　85.0%　after　5　times　of　desorption　and　recycling.　©　2025　Editorial　Office　of　Industrial　Water　Treatment,　CNOOC　Tianjin　Chemical　Research　and　Design　Institute　Co.,　Ltd.　All　rights　reserved.