A　novel　dual-function　ZnAl–LDH/Bi4O5Br2　nanocomposite　photocatalyst　was　synthesized　using　a　self-assembly　process　and　optimized　by　response　surface　methodology　for　the　advanced　treatment　of　wastewater　micropollutants.　A　series　of　characterizations　revealed　that　ZnAl–LDH/Bi4O5Br2　exhibits　suitable　heterojunction　structure　and　excellent　optoelectronic　properties.　As　a　result,　ZnAl–LDH/Bi4O5Br2　achieved　the　near-complete　removal　of　bisphenol　A　(BPA)　after　120　min　through　a　synergistic　process　of　adsorption　and　visible-light　photocatalysis.　The　corresponding　reaction　rate　constant　for　photocatalytic　degradation　approached　0.14　min−1,　which　is　significantly　higher　than　those　by　Bi4O5Br2　and　ZnAl–LDH.　Regarding　the　enhanced　BPA　removal　over　ZnAl–LDH/Bi4O5Br2,　the　adsorption　behavior　occurred　via　hydrogen　bonding　and　π-π　stacking　interactions,　while　the　photocatalytic　degradation　involved　the　efficient　photoexcitation　and　separation　of　charge　carriers　for　the　formation　of　reactive　oxygen　species　(ROS)　under　the　heterojunction　effect.　Electron　spin　resonance　(ESR)　and　radical　quenching　experiments　indicated　that　ROS　including　·OH,　·O2−,　and　1O2,　mainly　contribute　to　BPA　degradation.　The　predominant　ROS　formation　mechanism　was　the　interfacial　reactions　of　the　nanocomposite　with　H2O　molecules,　as　verified　by　the　density　of　states,　charge　density　differences,　and　adsorption　energy　calculations.　Furthermore,　the　intermediate　products　of　BPA　degradation　were　identified,　the　degradation　pathways　were　proposed,　and　the　related　ecotoxicity　consequences　were　evaluated.　This　study　confirmed　that　ZnAl–LDH/Bi4O5Br2　has　superior　synergistic　adsorptive　and　photocatalytic　performance,　offering　guidance　in　the　further　construction　and　application　of　functional　nanocomposites　for　wastewater　treatment.　©　2025　Elsevier　Inc.