Design of protein-based carriers for curcumin with tailored particle properties: Stability and mechanistic insights - Details

author：

Huang, Wenting (Huang, Wenting.) ^[1] | Hong, Zhiping (Hong, Zhiping.) ^[2] | Fu, Zhijie (Fu, Zhijie.) ^[3] | Meng, Chun (Meng, Chun.) ^[4] (Scholars：孟春) | Mao, Yuhong (Mao, Yuhong.) ^[5] (Scholars：茅宇虹) Unfold

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Abstract：

Curcumin＇s　(Cur,　C)　utility　is　restricted　by　poor　solubility,　stability,　and　bioavailability.　This　study　optimized　zein　(Z)-centered　core-shell　nanoparticles　using　soluble　pea　protein　(Psup)　or　whey　protein　isolate　(WPI,　W)　as　the　shell.　pH-shifting　enhanced　Cur　loading　to　316.3　μg/mg　(PsupZC)　and　266.1　μg/mg　(WZC),　surpassing　simple　complexation,　which　left　exposed　Cur　crystals　after　lyophilization.　Core-shell　ratios　controls　particle　sizes　(50–102　nm　for　PsupZC;　30–80　nm　for　WZC)　with　polydispersity　index　©　2024

Keyword：

Core shell nanoparticles Glycoproteins Hydrogen bonds

Community：

[ 1 ] [Huang, Wenting]Fujian Key Laboratory of Marine Enzyme Engineering, College of Biological Science and Technology, Fuzhou University, Fuzhou; 350116, China
[ 2 ] [Hong, Zhiping]Fujian Key Laboratory of Marine Enzyme Engineering, College of Biological Science and Technology, Fuzhou University, Fuzhou; 350116, China
[ 3 ] [Fu, Zhijie]Fujian Key Laboratory of Marine Enzyme Engineering, College of Biological Science and Technology, Fuzhou University, Fuzhou; 350116, China
[ 4 ] [Meng, Chun]Fujian Key Laboratory of Marine Enzyme Engineering, College of Biological Science and Technology, Fuzhou University, Fuzhou; 350116, China
[ 5 ] [Mao, Yuhong]Fujian Key Laboratory of Marine Enzyme Engineering, College of Biological Science and Technology, Fuzhou University, Fuzhou; 350116, China

Reprint 's Address：

茅宇虹
[mao, yuhong]fujian key laboratory of marine enzyme engineering, college of biological science and technology, fuzhou university, fuzhou; 350116, china

Email：

yuhong.mao@fzu.edu.cn

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