Healing　of　chronic　wounds　becomes　a　global　health　issue　due　to　increasing　incidence　and　associated　burdens,　and　therefore　promoting　tissue-remodeling　and　monitoring　wound-status　visually　are　of　particular　significance.　Herein,　an　electronic-skin　patch　(TENG-gel)　composed　by　polydimethylsiloxane/polytetrafluoroethylene　film,　eutectic　gallium–indium　(E-GaIn),　and　quaternary　chitosan/polyacrylamide/sodium　alginate@molybdenum　disulfide　(MoS2)　nanosheet　(HQPS@MoS2)　composite　hydrogel　is　assembled　layer-by-layer.　First,　the　TENG-gel　realizes　multimodal　antibacterial　by　integrating　peroxidase-like　activity,　photothermal　therapy,　and　nano-knife　effect,　which　eliminates　both　Gram-positive/negative　bacteria　with　killing　ratio　of　above　95%.　Besides,　electrical　stimulation　generated　from　the　TENG-gel　promotes　migration　of　fibroblasts　after　an　incubation　of　48 h　by　activating　signaling　pathways,　and　meanwhile　accelerates　vascularization　by　secreting　different　growth　factors　of　CD31,　VEGF,　and　TGF-β.　Through　providing　an　ideal　microenvironment　for　tissue　repair,　the　TENG-gel　achieves　1.6-fold　new　hair　follicles　and　2.4-fold　collagen　deposition　compared with　those　of　the　control　group.　More　interestingly,　dual　temperature-/strain-sensing　performance　enables　the　TENG-gel　with　capability　of　monitoring　wound　status　or　reminding　external　danger　signals　in　real-time　dependent　on　variational　electrical　signals.　Overall,　unique　advantages　of　such　smart　electronic-skin　patch　provide　a　personalized　medicine　strategy　for　realizing　tissue　reconstruction　and　monitoring　synchronously.　©　2025　Wiley-VCH　GmbH.