Recently,　the　quantum　anomalous　Hall　effect　(QAHE)　has　been　theoretically　proposed　in　compensated　antiferromagnetic　systems　by　using　the　magnetic　topological　insulator　model　[Phys.　Rev.　Lett.　134,　116603　(2025)10.1103/PhysRevLett.134.116603].　However,　the　related　and　systematic　study　based　on　a　realistic　material　system　is　still　limited.　As　the　only　experimentally　realized　antiferromagnetic　topological　insulator,　MnBi2Te4　becomes　a　vital　platform　for　exploring　various　topological　states.　In　this　work,　by　using　comprehensive　first-principles　calculations,　we　illustrate　that　the　QAHE　can　also　be　realized　in　compensated　antiferromagnetic　even-septuple-layer　MnBi2Te4　without　combined　parity-time　(PT)　symmetry.　Using　a　magnetic　topological　insulator　model,　the　layer-resolved　Chern　number　is　calculated　to　further　understand　the　presence　of　different　Chern　numbers.　The　application　of　external　hydrostatic　pressure　will　strengthen　the　Te-Te　quasicovalent　bond　due　to　the　dramatic　compression　of　the　van　der　Waals　gap.　Thus,　the　topological　nontrivial　gap　exceeds　the　room-temperature　energy　scale　in　a　wide　range　of　pressures.　Additionally,　we　find　that　constructing　MnBi2Te4/CrI3　heterostructure　can　realize　the　compensated　antiferromagnetic　configurations　with　QAHE.　Our　work　demonstrates　the　realization　of　QAHE　in　compensated　antiferromagnetic　even-septuple-layer　MnBi2Te4　and　provides　a　reliable　strategy　to　obtain　the　corresponding　magnetic　configurations.　©　2025　American　Physical　Society.