Ethyl　acetate　(EA)　is　a　stable　oxygenated　volatile　organic　compound　(VOC)　that　is　challenging　to　fully　degrade　due　to　its　strong　chemical　bonds.　High-entropy　metal　oxides　(HEOs)　with　their　active　lattice　oxygens　and　diverse　metal-oxygen　bonds　hold　great　potential　for　efficient　degradation　of　EA.　However,　synthesizing　HEOs　without　phase　separation　remains　a　significant　challenge.　In　this　study,　we　developed　an　electrospinning　method　to　synthesize　spinel-type　high-entropy　(CoMnNiFeZn)Ox　catalysts,　achieving　90%　EA　conversion　at　266　degrees　C　with　a　CO2　selectivity　of　100%.　The　catalyst　demonstrated　a　high　turnover　frequency　of　101.5　+/-　0.8　h-1　based　on　the　total　metal　content.　The　optimal　1　mmol-HEO　catalyst　demonstrated　excellent　stability　in　both　five-cycle　and　thermal　stability　tests.　An　18O　isotope-labelled　experiment　confirmed　that　the　oxidation　of　EA　follows　the　Marsvan-Krevelen　mechanism,　with　high　lattice　oxygen　mobility　significantly　enhancing　catalytic　activity.　Furthermore,　in　situ　diffuse　reflectance　infrared　Fourier　transform　spectroscopy　provided　insights　into　the　roles　of　different　metal-oxygen　bonds　in　the　catalytic　mechanism.　This　work　deepens　the　understanding　of　metal-oxygen　bond　interactions　in　the　oxidation　of　oxygenated　VOCs　and　offers　a　viable　approach　for　synthesizing　HEOs.　(sic)(sic)(sic)(sic)(EA)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic),　(sic)(sic)(sic)(sic)　(sic)(sic)(sic)(sic)(sic),　(sic)(sic)(sic)(sic).　(sic)(sic)(sic)(sic)(sic)(sic)(sic)(HEO)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)　(sic)(sic)(sic)-(sic)(sic)(sic)(sic)(sic)(sic)(sic)EA(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic).　(sic)(sic)(sic)(sic)(sic)(sic),　(sic)(sic)(sic)　(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)HEO,　(sic)266　degrees　C(sic)(sic)(sic)(sic)90%(sic)　EA(sic)(sic)(sic),　CO2　(sic)(sic)(sic)(sic)100%.　1　mmol　HEO(sic)(sic)(sic)(sic)(sic)(sic)　101.5　+/-　0.8　h-1(sic)(sic)(sic)(sic)(sic),　(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)　(sic)(sic)(sic)(sic)(sic).　(sic)(sic)18O(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)EA(sic)(sic)(sic)(sic)(sic)Mars-van　Krevelen(sic)(sic),　(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic).　(sic)(sic),　(sic)(sic)(sic)(sic)　(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)-(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)　(sic)(sic).　(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)-(sic)(sic)(sic)(sic)　(sic)(sic)(sic)(sic)(sic),　(sic)(sic)(sic)(sic)HEO(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic).