Owing　to　the　harsh　working　environment　in　which　mining　trucks　operate,　tires　tend　to　fail　prematurely.　In　this　study,　using　53/80R63　tires　as　the　research　object,　two-　and　three-dimensional　finite　element　models　(FEM)　of　tires　were　established.　A　steady-state　rolling　simulation　analysis　was　carried　out.　A　crack　growth　test　was　performed　on　the　rubber　material,　and　the　test　data　were　fitted　using　the　least　squares　method　to　obtain　the　fatigue　parameters　required　in　this　study.　According　to　the　simulation　results　of　steady-state　rolling,　fatigue　life　prediction　under　different　working　conditions　was　performed　using　fe-safeTM　software,　and　the　effects　of　different　load　rates,　inflation　pressures,　and　vehicle　speeds　on　tire　fatigue　life　were　analyzed.　The　results　show　that　when　the　inflation　pressure　and　vehicle　speed　were　constant,　with　an　increase　in　load,　the　life　of　the　belt　layer　and　the　sidewall　part　gradually　decreased,　and　the　life　of　the　chewing　rubber　part　displayed　a　sharp　decreasing　trend.　Under　the　condition　of　constant　load　and　vehicle　speed,　with　an　increase　of　inflation　pressure,　the　life　of　the　belt　layer　gradually　decreased,　and　the　life　of　the　sidewall　part　decreased　significantly.　Under　constant　load　and　inflation　pressure,　vehicle　speed　had　little　effect　on　the　tire　fatigue　life.