As　a　bridge　structure　with　good　robustness,　through　tied-arch　bridge　often　has　bridge　collapse　accidents　caused　by　suspender　failure.　To　study　the　collapse　failure　mechanism　of　through　tied-arch　bridge　considering　the　systematic　failure　of　suspenders,　the　importance　of　each　suspender　in　the　bridge　is　evaluated,　and　the　most　unfavorable　suspender　breaking　condition　of　the　bridge　is　judged.　On　this　basis,　based　on　a　real　multi-span　tied-arch　bridge,　the　failure　path　and　failure　mechanism　of　through　tied-arch　bridges　with　different　structural　types　under　the　systematic　failure　of　suspenders　are　studied,　and　the　influencing　factors　of　different　failure　mechanisms　are　compared　and　analyzed.　The　results　show　that　for　the　through　tied-arch　bridge,　the　breaking　of　the　short　suspender　has　little　effect　on　the　damage　of　the　remaining　structure　of　the　bridge.　When　the　long　suspender　is　broken,　it　is　easy　to　cause　the　adjacent　suspender　force　to　exceed　its　structural　redundancy　and　break.　Under　the　most　unfavorable　suspender　breaking　condition,　the　failure　of　4　pairs　of　suspenders　can　lead　to　the　systematic　failure　of　the　remaining　suspenders　of　a　multi-span　tied-arch　bridge,　resulting　in　the　loss　of　all　suspenders　of　the　bridge,　and　there　is　no　force　transmission　component　between　the　arch　rib　and　the　bridge　system,　so　that　the　bridge　system　and　the　arch　rib　have　different　degrees　of　damage.