Pickering　emulsions　are　dispersions　of　two　immiscible　liquids　stabilized　by　surface-active　colloidal　nano-/microparticles.　Their　compartmentalized　structures　closely　resemble　the　characteristics　of　cellular　and　subcellular　systems,　enabling　the　development　of　biomimetic　microreactors　that　enhance　catalytic　processes.　By　enlarging　interfacial　areas　while　effectively　partitioning　reactants　into　their　preferred　phases,　Pickering　emulsion-based　microreactors　improve　kinetic　parameters　and　prevent　unwanted　interactions.　The　adaptability　of　Pickering　emulsions　is　further　augmented　through　modifications　to　the　properties　and　composition　of　the　particle　emulsifiers,　rendering　them　multifunctional　and　facilitating　efficient　reactions　between　immiscible　phases,　such　as　oil　and　water,　especially　when　the　emulsifiers　themselves　act　as　catalysts.　This　review　summarizes　recent　advances　in　Pickering　emulsion-based　biomimetic　microreactors,　focusing　on　the　versatile　choice　of　various　particles,　design　principles,　and　their　applications　in　facilitating　biphasic　catalysis　in　a　biomimetic　way.　We　also　discuss　the　challenges　and　future　perspectives　for　further　refining　these　microreactors　for　enhanced　biphasic　catalytic　processes.　©　2025　The　Royal　Society　of　Chemistry.