Rapid sorting and auxiliary evaluation of malignant breast tumors by accurate imaging analysis of metastasis-related biomarker - Details

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Accurate　differentiation　of　benign　and　malignant　breast　tumors　is　paramount　for　establishing　schemes　of　breast　cancer　treatment　and　prognosis.　Here　we　report　a　near-infrared　(NIR)　fluorescence　probe　(YF-1)　with　the　overexpressed　cathepsin　C　(CTSC)　in　metastatic　breast　tumors　as　the　detecting　substrate.　This　probe　allows　accurate　identification　of　malignant　tumor　tissue　specimens　among　tumor　tissue　specimens　with　unknown　properties　in　a　blind　study.　Importantly,　a　series　of　visible　to　NIR　CTSC-activated　fluorescence　probes　based　on　the　same　strategy　realize　effective　identification　of　malignant　tumor　tissues,　suggesting　that　CTSC　could　be　the　specific　identification　substrate　of　malignant　breast　tumors.　Furthermore,　a　hydrophilic　PEG　moiety　is　coupled　into　YF-1,　producing　another　CTSC-activated　NIR　probe　(YF-2).　YF-2　has　excellent　tumor-targeting　capability,　enabling　the　visualization　of　lung-metastatic　breast　tumors.　The　excellent　detection　accuracy　and　construction　versatility　of　CTSC　probes　pave　the　way　for　preoperative　diagnosis　of　malignant　breast　tumors.　Copyright　©　2025　The　Authors,　some　rights　reserved.

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[ 1 ] [Zuo S.]State Key Laboratory of Chemo and Biosensing, College of Chemistry and Chemical Engineering, Hunan University, Changsha, 410082, China
[ 2 ] [Li Y.]State Key Laboratory of Chemo and Biosensing, College of Chemistry and Chemical Engineering, Hunan University, Changsha, 410082, China
[ 3 ] [Chen Y.]MOE Key Laboratory for Analytical Science of Food Safety and Biology, Fujian Provincial Key Laboratory of Analysis and Detection Technology for Food Safety, College of Chemistry, Fuzhou University, Fuzhou, 350108, China
[ 4 ] [Jiang G.]State Key Laboratory of Chemo and Biosensing, College of Chemistry and Chemical Engineering, Hunan University, Changsha, 410082, China
[ 5 ] [Zhou Z.]State Key Laboratory of Chemo and Biosensing, College of Chemistry and Chemical Engineering, Hunan University, Changsha, 410082, China
[ 6 ] [Ren T.-B.]State Key Laboratory of Chemo and Biosensing, College of Chemistry and Chemical Engineering, Hunan University, Changsha, 410082, China
[ 7 ] [Chen L.]MOE Key Laboratory for Analytical Science of Food Safety and Biology, Fujian Provincial Key Laboratory of Analysis and Detection Technology for Food Safety, College of Chemistry, Fuzhou University, Fuzhou, 350108, China
[ 8 ] [Liu S.]Department of Hepatobiliary Surgery, Central Laboratory, Hunan Provincial People’s Hospital, The First Affiliated Hospital of Hunan Normal University, Changsha, 410005, China
[ 9 ] [Huang S.]Department of Breast and Thyroid Surgery, Hunan Provincial People’s Hospital, The First Affiliated Hospital of Hunan Normal University, Changsha, 410005, China
[ 10 ] [Zhang X.-B.]State Key Laboratory of Chemo and Biosensing, College of Chemistry and Chemical Engineering, Hunan University, Changsha, 410082, China
[ 11 ] [Yuan L.]State Key Laboratory of Chemo and Biosensing, College of Chemistry and Chemical Engineering, Hunan University, Changsha, 410082, China

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Science Advances

ISSN： 2375-2548

Year： 2025

Issue： 14

Volume： 11

1 1 . 7 0 0

JCR@2023

CAS Journal Grade：1

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ESI Highly Cited Papers on the List： 0 Unfold All

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