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author:

Li, Hongsheng (Li, Hongsheng.) [1] | Li, Wenjun (Li, Wenjun.) [2] | Zheng, Cheng (Zheng, Cheng.) [3] | Ding, Lei (Ding, Lei.) [4] | Ke, Jianmei (Ke, Jianmei.) [5] | Wu, Ming (Wu, Ming.) [6] | Liu, Xiaolong (Liu, Xiaolong.) [7] | Zhang, Xiaolong (Zhang, Xiaolong.) [8] | Zeng, Yongyi (Zeng, Yongyi.) [9]

Indexed by:

Scopus SCIE

Abstract:

The development of efficient photosensitizer agents is crucial for cancer phototherapy. However, conventional photosensitizers often suffer from low tumor selectivity and poor retention in tumor, while single-modal therapies such as photodynamic therapy (PDT) or photothermal therapy (PTT) often exhibit diminished efficacy. Herein, we have developed a H2S activated gold nanoparticle (AuNPs)-DNA nanomachine for tumor targeting, fluorescence imaging and combination therapy using PDT and PTT. The nanomachine consists of G-quadruplex AS1411 aptamer (serving as both a targeting ligand and a carrier for the photosensitizer, Ce6) and AuNPs (serving as a DNA carrier and PTT agent after response to H2S). Upon activation by H2S, which is overexpressed in tumors, the system releases AS1411-Ce6 and causes aggregation of AuNPs, resulting in an absorbance red shift to the near-infrared (NIR) region. Upon laser irradiation, the released AS1411-Ce6 generated reactive oxygen species for PDT (using a 660 nm laser), while the aggregated AuNPs enhanced the PTT effect (using an 808 nm laser). Both in vitro and in vivo experiments demonstrated that this dual-modal phototherapy significantly inhibited tumor growth. Therefore, the tumor microenvironment biomarker responsive nanomachine represents a promising nanoplatform for combinatorial tumor therapy.

Keyword:

Aggregation AS1411 Gold nanoparticles H2S Phototherapy

Community:

  • [ 1 ] [Li, Hongsheng]Fujian Med Univ, Affiliated Hosp 1, Liver Dis Ctr, Fuzhou 350005, Peoples R China
  • [ 2 ] [Li, Wenjun]Fujian Med Univ, Affiliated Hosp 1, Liver Dis Ctr, Fuzhou 350005, Peoples R China
  • [ 3 ] [Zhang, Xiaolong]Fujian Med Univ, Affiliated Hosp 1, Liver Dis Ctr, Fuzhou 350005, Peoples R China
  • [ 4 ] [Zeng, Yongyi]Fujian Med Univ, Affiliated Hosp 1, Liver Dis Ctr, Fuzhou 350005, Peoples R China
  • [ 5 ] [Li, Hongsheng]Fujian Med Univ, Mengchao Hepatobiliary Hosp, United Innovat Mengchao Hepatobiliary Technol Key, Fuzhou 350007, Peoples R China
  • [ 6 ] [Li, Wenjun]Fujian Med Univ, Mengchao Hepatobiliary Hosp, United Innovat Mengchao Hepatobiliary Technol Key, Fuzhou 350007, Peoples R China
  • [ 7 ] [Ding, Lei]Fujian Med Univ, Mengchao Hepatobiliary Hosp, United Innovat Mengchao Hepatobiliary Technol Key, Fuzhou 350007, Peoples R China
  • [ 8 ] [Ke, Jianmei]Fujian Med Univ, Mengchao Hepatobiliary Hosp, United Innovat Mengchao Hepatobiliary Technol Key, Fuzhou 350007, Peoples R China
  • [ 9 ] [Wu, Ming]Fujian Med Univ, Mengchao Hepatobiliary Hosp, United Innovat Mengchao Hepatobiliary Technol Key, Fuzhou 350007, Peoples R China
  • [ 10 ] [Liu, Xiaolong]Fujian Med Univ, Mengchao Hepatobiliary Hosp, United Innovat Mengchao Hepatobiliary Technol Key, Fuzhou 350007, Peoples R China
  • [ 11 ] [Zhang, Xiaolong]Fujian Med Univ, Mengchao Hepatobiliary Hosp, United Innovat Mengchao Hepatobiliary Technol Key, Fuzhou 350007, Peoples R China
  • [ 12 ] [Zeng, Yongyi]Fujian Med Univ, Mengchao Hepatobiliary Hosp, United Innovat Mengchao Hepatobiliary Technol Key, Fuzhou 350007, Peoples R China
  • [ 13 ] [Li, Hongsheng]Fuzhou Univ, Coll Biol Sci & Engn, Fuzhou 350116, Peoples R China
  • [ 14 ] [Li, Wenjun]Fuzhou Univ, Coll Biol Sci & Engn, Fuzhou 350116, Peoples R China
  • [ 15 ] [Wu, Ming]Fuzhou Univ, Coll Biol Sci & Engn, Fuzhou 350116, Peoples R China
  • [ 16 ] [Liu, Xiaolong]Fuzhou Univ, Coll Biol Sci & Engn, Fuzhou 350116, Peoples R China
  • [ 17 ] [Zhang, Xiaolong]Fuzhou Univ, Coll Biol Sci & Engn, Fuzhou 350116, Peoples R China
  • [ 18 ] [Zeng, Yongyi]Fuzhou Univ, Coll Biol Sci & Engn, Fuzhou 350116, Peoples R China
  • [ 19 ] [Zheng, Cheng]Fuzhou Univ, Coll Chem, Fuzhou 350116, Peoples R China
  • [ 20 ] [Ding, Lei]Univ Sci & Technol China, Sch Rare Earths, Hefei 230026, Peoples R China
  • [ 21 ] [Ke, Jianmei]Univ Sci & Technol China, Sch Rare Earths, Hefei 230026, Peoples R China

Reprint 's Address:

  • 张晓龙 曾永毅

    [Zhang, Xiaolong]Fujian Med Univ, Affiliated Hosp 1, Liver Dis Ctr, Fuzhou 350005, Peoples R China;;[Zeng, Yongyi]Fujian Med Univ, Affiliated Hosp 1, Liver Dis Ctr, Fuzhou 350005, Peoples R China

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Source :

SENSORS AND ACTUATORS B-CHEMICAL

Year: 2025

Volume: 436

8 . 0 0 0

JCR@2023

Cited Count:

WoS CC Cited Count:

SCOPUS Cited Count:

ESI Highly Cited Papers on the List: 0 Unfold All

WanFang Cited Count:

Chinese Cited Count:

30 Days PV: 3

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