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The development of efficient photosensitizer agents is crucial for cancer phototherapy. However, conventional photosensitizers often suffer from low tumor selectivity and poor retention in tumor, while single-modal therapies such as photodynamic therapy (PDT) or photothermal therapy (PTT) often exhibit diminished efficacy. Herein, we have developed a H2S activated gold nanoparticle (AuNPs)-DNA nanomachine for tumor targeting, fluorescence imaging and combination therapy using PDT and PTT. The nanomachine consists of G-quadruplex AS1411 aptamer (serving as both a targeting ligand and a carrier for the photosensitizer, Ce6) and AuNPs (serving as a DNA carrier and PTT agent after response to H2S). Upon activation by H2S, which is overexpressed in tumors, the system releases AS1411-Ce6 and causes aggregation of AuNPs, resulting in an absorbance red shift to the near-infrared (NIR) region. Upon laser irradiation, the released AS1411-Ce6 generated reactive oxygen species for PDT (using a 660 nm laser), while the aggregated AuNPs enhanced the PTT effect (using an 808 nm laser). Both in vitro and in vivo experiments demonstrated that this dual-modal phototherapy significantly inhibited tumor growth. Therefore, the tumor microenvironment biomarker responsive nanomachine represents a promising nanoplatform for combinatorial tumor therapy.
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SENSORS AND ACTUATORS B-CHEMICAL
Year: 2025
Volume: 436
8 . 0 0 0
JCR@2023
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ESI Highly Cited Papers on the List: 0 Unfold All
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30 Days PV: 3