High-temperature　proton　exchange　membrane　fuel　cells　(HT-PEMFCs)　show　broad　application　perspectives　due　to　their　faster　reaction　kinetics　and　tolerance　to　fuel/gas　impurities　as　well　as　the　easy　water/heat　managements.　However,　the　catalysts　and　subsequent　membrane　electrode　assemblies　(MEAs)　are　still　suffering　from　performance　degradation,　which　severely　restricts　HT-PEMFCs＇　large-scale　practical　application.　To　overcome　the　challenges,　developing　high-performance　catalysts　and　MEAs　with　advanced　materials　and　optimized　structures　to　achieve　stable　and　efficient　operation　of　HT-PEMFCs　is　necessary.　To　facilitate　the　research　and　development　of　HT-PEMFCs,　a　comprehensive　overview　of　the　latest　developments　in　the　design　of　active　and　stable　catalysts　and　durable　MEAs　is　presented　in　this　paper.　This　review　systematically　summarizes　the　degradation　mechanisms　of　catalysts,　and　corresponding　mitigation　strategies　for　improving　the　stability　of　catalysts　and　MEAs,　aiming　to　effectively　developing　high-performance　and　durable　HT-PEMFCs.　Furthermore,　the　main　challenges　are　analyzed　and　the　future　research　directions　for　overcoming　the　challenges　are　also　proposed　for　developing　highactive　and　stable　catalysts　and　MEAs　used　in　HT-PEMFCs　toward　practical　applications.