Pt/Ni-Fe-MOF　nanosheets　(NSs),　with　small　sized　Pt　nanoparticles　of　ca.　2　nm　deposited　on　2D　Ni-Fe-MOF　NSs　of　ca.　5.5　nm,　were　successfully　fabricated　and　was　used　as　a　multifunctional　catalyst　for　one-pot　reaction　between　o-phenylenediamines　and　alcohols　to　produce　benzimidazoles　under　visible　light.　By　modulation　on　the　reaction　medium　and　the　composition　of　the　catalyst　to　regulate　the　individual　reaction　step　involved,　an　optimum　activity　was　achieved　over　4　wt%　Pt/Ni-Fe-MOF　NSs　in　a　mixed　solvent　of　benzyl　alcohol/toluene　(v/v,　2/1),　which　showed　a　superior　yield　of　92.0　%　to　2-phenylbenzimidazole.　In　comparison　with　its　bulk　counterpart,　the　superior　activity　observed　over　2D　Pt/Ni-Fe-MOF　NSs　can　be　attributed　to　a　reduced　recombination　of　the　photogenerated　charge　carriers　due　to　their　short　transportation　path.　This　study　first　demonstrated　that　in　addition　to　the　different　catalytic　sites　required,　the　individual　reaction　step　involved　in　a　one-pot　tandem/cascade　reaction　can　be　regulated　to　enable　an　efficient　whole　reaction.　Such　a　regulation　of　the　rate　of　the　individual　reaction　step　can,　to　a　certain　degree,　be　achieved　by　modulation　on　the　reaction　medium　and　the　component　of　the　multifunctional　catalyst.　This　study　also　provides　the　great　potential　of　using　2D　MOF　for　the　construction　of　multifunctional　catalysts　for　light　initiated　one-pot　tandem/cascade　reaction.