As　a　typical　proinflammatory　cytokine,　interleukin　6　(IL-6)　exhibits　great　influence　on　treating　diseases　(e.g.,　urocystitis)　and　adjusting　immune.　Normally,　the　IL-6　degree　keeps　a　low　content　(＜　40.0 pg mL−1)　in　bodies,　but　when　its　degree　becomes　higher,　several　serious　conditions　(e.g.,　urocystitis　and　infections)　may　occur.　Hence,　it　is　very　essential　to　design　a　highly　effective　technology　for　monitoring　IL-6　as　a　biomarker.　In　the　present　work,　through　adopting　carbon　black　(CB)　as　substrate　substance,　o-diaminobenzene　as　electropolymerized　monomer　and　[Fe(CN)6]4−/3−　as　the　signal　probe,　a　low-cost,　sensitive　and　simple　molecularly　imprinted　polymer　(MIP)　electrochemical　sensing　platform　was　designed　to　detect　the　IL-6　degree.　The　experiments　revealed　that　the　current　of　[Fe(CN)6]4−/3−　probe　at　the　MIP　sensor　would　decrease　along　with　the　increase　of　IL-6　degree.　Owing　to　the　prominent　properties　of　CB　(e.g.,　high　conductivity　and　surface　area　as　well　as　stability)　and　high　target-recognition　capability　of　MIP,　the　as-proposed　MIP　sensor　offers　wide　linearity　(0.1–800 pg mL−1)　and　low　analytical　limit　(0.03 pg mL−1);　meanwhile,　it　possesses　good　repeatability,　stability,　and　practical　applications.　It　is,　thus,　expected　this　simple　MIP　sensor　has　some　application　value　for　IL-6　detection.　©　The　Author(s),　under　exclusive　licence　to　The　Japan　Society　for　Analytical　Chemistry　2025.