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author:

Lin, Minghang (Lin, Minghang.) [1] | Yan, Lei (Yan, Lei.) [2] | He, Mei (He, Mei.) [3] | Chen, Shuqiang (Chen, Shuqiang.) [4]

Indexed by:

EI SCIE

Abstract:

Objective: This study aimed to develop and validate a diagnostic model for gouty arthritis by integrating ultrasonographic radiomic features with clinical parameters. Methods: A total of 604 patients suspected of having gouty arthritis were enrolled and randomly divided into a training set (n = 483) and a validation set (n = 121) in a 4:1 ratio. Univariate and multivariate analyses were conducted on the clinical data to identify statistically significant clinical features for constructing an initial diagnostic model. Key radiomic features were identified in the training set using least absolute shrinkage and selection operator (LASSO) regression analysis to establish a radiomic model. A composite clinicoradiomic nomogram was then developed by combining clinical (such as C-reactive protein, erythrocyte sedimentation rate and uric acid level) and radiomic features through logistic regression. The predictive performance of the clinical model, radiomic model and clinicoradiomic nomogram was evaluated in the validation set using receiver operating characteristic curves, calibration curves and decision curve analysis. Results: The clinicoradiomic nomogram, which integrated imaging features and clinical characteristics via logistic regression, demonstrated superior predictive performance in the validation set, with an area under the curve (AUC) of 0.936(95% CI: 0.885-0.986), surpassing both clinical (AUC = 0.924; 95% CI: 0.873-0.976) and radiomic models (AUC = 0.828; 95% CI: 0.738-0.918) alone. Decision curve analysis further confirmed the clinical utility of this model, particularly in differentiating between gouty and non-gouty arthritis. Conclusion: Compared with standalone clinical or radiomic models, the ultrasonography-based clinicoradiomic model exhibited enhanced predictive accuracy for diagnosing gouty arthritis, presenting a novel and promising approach for the early diagnosis and management of gouty arthritis.

Keyword:

Gouty arthritis Nomogram Radiomics Ultrasound

Community:

  • [ 1 ] [Lin, Minghang]Fujian Med Univ, Shengli Clin Med Coll, Fuzhou, Fujian, Peoples R China
  • [ 2 ] [Chen, Shuqiang]Fujian Med Univ, Shengli Clin Med Coll, Fuzhou, Fujian, Peoples R China
  • [ 3 ] [Lin, Minghang]Fujian Med Univ, Fuqing City Hosp, Dept Ultrasound, Fuqing, Peoples R China
  • [ 4 ] [Lin, Minghang]Fuzhou Univ, Affiliated Prov Hosp, Dept Ultrasound, Fuzhou, Fujian, Peoples R China
  • [ 5 ] [He, Mei]Fuzhou Univ, Affiliated Prov Hosp, Dept Ultrasound, Fuzhou, Fujian, Peoples R China
  • [ 6 ] [Chen, Shuqiang]Fuzhou Univ, Affiliated Prov Hosp, Dept Ultrasound, Fuzhou, Fujian, Peoples R China
  • [ 7 ] [Yan, Lei]Fujian Med Univ, Affiliated Hosp 1, Dept Ultrasound, Fuzhou, Peoples R China
  • [ 8 ] [Yan, Lei]Fujian Med Univ, Affiliated Hosp 1, Natl Reg Med Ctr, Binhai Campus, Fuzhou, Peoples R China

Reprint 's Address:

  • 待查

    [Chen, Shuqiang]Fuzhou Univ, Fujian Med Univ, Dept Ultrasound, Shengli Clin Med Coll,Affiliated Prov Hosp, 134,East St, Fuzhou 350300, Fujian, Peoples R China

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Source :

ULTRASOUND IN MEDICINE AND BIOLOGY

ISSN: 0301-5629

Year: 2025

Issue: 4

Volume: 51

Page: 650-660

2 . 4 0 0

JCR@2023

CAS Journal Grade:3

Cited Count:

WoS CC Cited Count:

SCOPUS Cited Count:

ESI Highly Cited Papers on the List: 0 Unfold All

WanFang Cited Count:

Chinese Cited Count:

30 Days PV: 0

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