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[期刊论文]

One-Pot Synthesis of Oxygen Vacancy-Rich Amorphous/Crystalline Heterophase CaWO4 Nanoparticles for Enhanced Radiodynamic-Immunotherapy

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author:

Peng, Shanshan (Peng, Shanshan.) [1] | Chen, Zhen (Chen, Zhen.) [2] | Wang, Jun (Wang, Jun.) [3] | Unfold

Indexed by:

EI

Abstract:

Radiodynamic therapy that employs X-rays to trigger localized reactive oxygen species (ROS) generation can tackle the tissue penetration issue of phototherapy. Although calcium tungstate (CaWO4) shows great potential as a radiodynamic agent benefiting from its strong X-ray absorption and the ability to generate electron–hole (e−-h+) pairs, slow charge carrier transfer and fast e−-h+ recombination greatly limit its ROS-generating performance. Herein, via a one-pot wet-chemical method, oxygen vacancy-rich amorphous/crystalline heterophase CaWO4 nanoparticles (Ov-a/c-CaWO4 NPs) with enhanced radiodynamic effect are synthesized for radiodynamic-immunotherapy of cancer. The phase composition and oxygen vacancy content of CaWO4 can be easily tuned by adjusting the solvothermal temperature. More intriguingly, the amorphous/crystalline interfaces and abundant oxygen vacancies accelerate charge carrier transfer and suppress e−-h+ recombination, respectively, enabling synergistically improved ROS production from X-ray-irradiated Ov-a/c-CaWO4 NPs. In addition to directly inducing oxidative damage of cancer cells, radiodynamic generation of ROS also boosts immunogenic cell death to provoke a systemic antitumor immune response, thereby allowing the inhibition of both primary and distant tumors as well as cancer metastasis. This study establishes a synergistic enhancement strategy involving the integration of phase and defect engineering to improve the ROS generation capacity of radiodynamic-immunotherapeutic anticancer nanoagents. © 2024 The Author(s). Advanced Science published by Wiley-VCH GmbH.

Keyword:

Cell death Cell engineering X ray absorption X ray production

Community:

  • [ 1 ] [Peng, Shanshan]New Cornerstone Science Laboratory, MOE Key Laboratory for Analytical Science of Food Safety and Biology, College of Chemistry, Fuzhou University, Fuzhou; 350108, China
  • [ 2 ] [Chen, Zhen]New Cornerstone Science Laboratory, MOE Key Laboratory for Analytical Science of Food Safety and Biology, College of Chemistry, Fuzhou University, Fuzhou; 350108, China
  • [ 3 ] [Wang, Jun]New Cornerstone Science Laboratory, MOE Key Laboratory for Analytical Science of Food Safety and Biology, College of Chemistry, Fuzhou University, Fuzhou; 350108, China
  • [ 4 ] [Yu, Meili]New Cornerstone Science Laboratory, MOE Key Laboratory for Analytical Science of Food Safety and Biology, College of Chemistry, Fuzhou University, Fuzhou; 350108, China
  • [ 5 ] [Niu, Xuegang]Department of Neurosurgery, Neurosurgery Research Institute, the First Affiliated Hospital of Fujian Medical University, Fuzhou; 350005, China
  • [ 6 ] [Cui, Tingting]Departments of Diagnostic Radiology, Surgery, Chemical and Biomolecular Engineering and Biomedical Engineering, Yong Loo Lin School of Medicine and College of Design and Engineering, National University of Singapore, Singapore; 117597, Singapore
  • [ 7 ] [Cui, Tingting]Institute of Molecular and Cell Biology, 61 Biopolis Drive, Proteos, Singapore; 138673, Singapore
  • [ 8 ] [Ao, Rujiang]New Cornerstone Science Laboratory, MOE Key Laboratory for Analytical Science of Food Safety and Biology, College of Chemistry, Fuzhou University, Fuzhou; 350108, China
  • [ 9 ] [Cai, Huilan]New Cornerstone Science Laboratory, MOE Key Laboratory for Analytical Science of Food Safety and Biology, College of Chemistry, Fuzhou University, Fuzhou; 350108, China
  • [ 10 ] [Huang, Hongwei]New Cornerstone Science Laboratory, MOE Key Laboratory for Analytical Science of Food Safety and Biology, College of Chemistry, Fuzhou University, Fuzhou; 350108, China
  • [ 11 ] [Lin, Lisen]New Cornerstone Science Laboratory, MOE Key Laboratory for Analytical Science of Food Safety and Biology, College of Chemistry, Fuzhou University, Fuzhou; 350108, China
  • [ 12 ] [Chen, Xiaoyuan]Departments of Diagnostic Radiology, Surgery, Chemical and Biomolecular Engineering and Biomedical Engineering, Yong Loo Lin School of Medicine and College of Design and Engineering, National University of Singapore, Singapore; 117597, Singapore
  • [ 13 ] [Chen, Xiaoyuan]Institute of Molecular and Cell Biology, 61 Biopolis Drive, Proteos, Singapore; 138673, Singapore
  • [ 14 ] [Yang, Huanghao]New Cornerstone Science Laboratory, MOE Key Laboratory for Analytical Science of Food Safety and Biology, College of Chemistry, Fuzhou University, Fuzhou; 350108, China

Reprint 's Address:

  • [lin, lisen]new cornerstone science laboratory, moe key laboratory for analytical science of food safety and biology, college of chemistry, fuzhou university, fuzhou; 350108, china;;

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Source :

Advanced Science

Year: 2025

Issue: 7

Volume: 12

1 4 . 3 0 0

JCR@2023

CAS Journal Grade:1

Cited Count:

WoS CC Cited Count:

30 Days PV: 2

Affiliated Colleges:

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