The　design　of　a　highly　stable　and　efficient　electrocatalyst　for　oxygen　evolution　reaction　(OER)　is　important　to　facilitate　the　large-scale　industrial　application　of　water　splitting.　Nevertheless,　the　preparation　of　electrocatalysts　that　combine　high　activity　and　stability　remains　a　significant　challenge.　In　this　work,　the　NiFe-LDH　electrocatalyst　with　highly　stable　and　active　was　fabricated　through　the　modulation　of　the　stable　interface　at　the　catalyst-substrate　interface.　The　findings　indicated　that　the　catalyst　stability　can　be　substantially　enhanced　by　modulating　the　synthesis　environment　to　achieve　a　tight　interlink　between　the　catalyst　and　the　substrate.　Based　on　these　findings,　further　loading　of　the　active　components　was　conducted　via　microwave　method,　to　prepare　highly　active　NiFe-LDH　electrode.　The　fabricated　NiFe-LDH　exhibited　superior　activity　on　OER　and　displayed　an　overpotential　of　230　mV　to　acquire　current　response　to　100　mA/cm2.　The　OER　catalysts　prepared　in　this　study　exhibited　remarkable　long-term　stability　at　a　current　density　of　10　mA/cm2　and　100　mA/cm2　for　more　than　40　h.　In　this　work,　an　interface　engineering　strategy　for　designing　highly　stable　catalytic　electrodes　was　proposed,　which　can　provide　a　new　idea　for　the　design　of　outstanding　stable　and　active　electrodes.