Mechanical　properties　and　integrity　of　biodegradable　Zn　alloys　during　degradation　holds　significant　importance.　In　this　study,　a　Zn-Mg-Mn　alloy　with　tensile　strength　of　414　MPa　and　an　elongation　of　26%　was　developed.　The　strength　contributions　of　as-extruded　Zn　alloy　from　grain　boundary　strengthening,　precipitation　strengthening,　and　second　phase　strengthening.　Degradation　of　the　Zn　alloy　in　Hank＇s　solution　exhibited　a　decreasing　trend　with　prolonged　immersion,　eventually　stabilizing　at　16　mu　m/year.　Corrosion　morphology　analysis　revealed　that　the　corrosion　modes　transformed　from　pitting　corrosion　to　severely　localized　corrosion　with　prolonged　immersion　time,　eventually　lead　to　formation　of　large　holes.　Although　the　tensile　strength　of　the　Zn　alloys　remained　relatively　unchanged　following　varied　immersion　time,　a　substantial　decrease　in　elongation　was　observed.　The　decreased　elongation　primarily　attributed　to　the　formation　of　surface　corrosion　pits　or　holes,　exacerbating　crack　propagation　during　tension.　Biocompatibility　assessments　of　Zn　alloys　demonstrated　that　a　50%　concentration　of　Zn　alloy　leach　solution　cultured　with　C3H10　and　RMSC　cells　yielded　cellular　activity　exceeding　80%,　indicating　excellent　cytocompatibility.　Alkaline　phosphatase　(ALP)　and　alizarin　red　staining　results　further　underscored　the　remarkable　early　and　late　osteogenic　properties　exhibited　by　Zn-Mg-Mn　alloy.