Background　We　attempted　to　establish　correlations　between　intraoperative　variables　such　as　time-to-isolation　(TTI)　and　temperature　(T)　at　the　30-second　mark,　and　the　sustained　efficacy　of　pulmonary　vein　isolation.　Methods　One　hundred　patients　underwent　repeat　procedures　subsequent　to　their　index　ablation.　Five　time　intervals　were　delineated　based　on　TTI　metrics　of　30,　35,　40,　45,　and　60　s　during　the　initial　procedure.　Subsequently,　temperatures　of　-25　degrees　C,　-29　degrees　C,　-30　degrees　C,　and　-　31　degrees　C　were　determined　at　30　nodes　during　repeat　procedures,　guided　by　the　findings　from　the　initial　intervention.　The　prevalence　of　re-established　pulmonary　vein　(PV)　potentials　was　assessed　both　prior　to　and　post　each　TTI　and　temperature　assessment　at　the　30-second　node.　Results　The　incidence　of　reconnected　PV　potentials　demonstrated　a　noteworthy　reduction　in　the　group　with　TTI　＜　30　s　group　than　in　the　TTI　＞=　30.　Similarly,　there　was　a　notable　decrease　in　the　incidence　of　reconnected　PV　potentials　in　the　group　with　T　at　30　s　of　＜　-31　degrees　C　than　＞=　-31　degrees　C.　The　sensitivity,　specificity,　and　positive　predictive　values　(PPVs)　for　predicting　durable　pulmonary　vein　isolation　were　13.19%,　94.44%,　and　83.72%,　respectively,　in　cases　where　the　TTI　was　＜　30　s　and　T　at　30　s　was　＜　-31　degrees　C.　Conclusion　Integrating　both　TTI30s　and　T30s　could　potentially　serve　as　an　effective　method　for　predicting　the　persistence　of　pulmonary　vein　isolation　using　second-generation　cryoballoons.