Papillary　thyroid　carcinoma　(PTC)　is　generally　a　slow-growing　disease　with　a　favorable　10-year　survival　rate.　However,　about　10%　of　PTC　cases　show　significant　aggressiveness,　with　tendencies　for　local　invasion　or　distant　metastasis,　the　mechanisms　of　which　remain　unclear.　This　study　aims　to　identify　predictive　indicators　and　explore　new　potential　targets　for　clinical　treatment,　highlighting　the　need　for　novel　biomarkers　and　therapeutic　targets.　We　analyzed　FBP1　expression　in　PTC　tissues.　Cell　proliferation,　apoptosis,　and　invasion　were　evaluated　with　and　without　FBP1　overexpression　in　PTC　cells　to　assess　FBP1＇s　effects.　We　then　investigated　whether　FBP1　reduces　PTC　cell　tumorigenesis　and　metastasis　by　regulating　HIF-1　alpha　expression.　FBP1　expression　was　reduced　in　PTC　samples　and　showed　a　negative　correlation　with　T　stage.　In　vitro　experiments　indicated　that　FBP1　acts　as　a　hypoxia　response　inhibitor,　regulating　tumor　cells.　Additionally,　FBP1　inhibited　the　proliferation,　apoptosis,　and　invasion　of　thyroid　cancer　cells　by　modulating　HIF-1　alpha　expression.　Our　results　provide　new　insights　into　the　role　of　FBP1　in　PTC　progression　and　indicate　that　targeting　the　FBP1-HIF-1　alpha　axis　could　be　a　promising　therapeutic　approach　for　this　disease.