Identification of novel antioxidant peptides from Lateolabrax japonicus and the underlying molecular mechanisms against oxidative stress injury in Caco-2 cells - Details

author：

Li, C. (Li, C..) ^[1] | Li, L. (Li, L..) ^[2] | Farag, M.A. (Farag, M.A..) ^[3] | Cai, X. (Cai, X..) ^[4] | Wang, S. (Wang, S..) ^[5]

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Abstract：

Antioxidants　are　crucial　for　balancing　free　radicals,　activating　the　body＇s　defense　system,　and　reducing　oxidative　stress.　Food-derived　antioxidant　peptides　have　broad　applications　in　food　and　biomedical　industries,　yet　understanding　their　complex　composition　and　molecular　mechanisms　remains　incomplete.　Our　previous　studies　have　indicated　that　bass　fish　(Lateolabrax　japonicus)　hydrolysates　(LPH)　possess　antioxidant　properties.　This　study　aimed　to　identify　and　analyze　novel　antioxidant　peptides　from　LPH　using　biochemical　and　computer-based　studies.　Five　novel　peptides　were　discovered,　including　AGFAGDDAPR,　DDWENWAK,　DWENWAK,　EWDNFAK,　and　WGEDGYIR,　with　DDWENWAK　showing　remarkable　antioxidant　effects.　DDWENWAK　protected　Caco-2　cells　against　H2O2-induced　oxidative　damage　and　improved　mitochondrial　energy　metabolism　via　Nrf2　and　AMPK　pathways.　Molecular　docking　affirmed　the　relationship　between　antioxidant　properties　and　peptide　structure,　highlighting　key　hydrogen　bonds　and　electrostatic　interactions　mediating　peptide-receptor　binding.　These　findings　provide　better　insight　into　the　antioxidant　peptides＇　action　mechanisms,　aiding　in　the　development　of　novel　peptides　for　antioxidant-functional　foods　or　pharmaceuticals.　©　2024　Elsevier　Ltd

Keyword：

Antioxidant Caco-2 cells Characterization Energy homeostasis Molecular docking

Community：

[ 1 ] [Li C.]College of Chemical Engineering, College of Biological Science and Engineering, Fuzhou University, Fuzhou, 350108, China
[ 2 ] [Li L.]College of Chemical Engineering, College of Biological Science and Engineering, Fuzhou University, Fuzhou, 350108, China
[ 3 ] [Farag M.A.]Pharmacognosy Department, Faculty of Pharmacy, Cairo University, Cairo, 11562, Egypt
[ 4 ] [Cai X.]College of Chemical Engineering, College of Biological Science and Engineering, Fuzhou University, Fuzhou, 350108, China
[ 5 ] [Wang S.]College of Chemical Engineering, College of Biological Science and Engineering, Fuzhou University, Fuzhou, 350108, China

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Source ：

Food Bioscience

ISSN： 2212-4292

Year： 2024

Volume： 62

4 . 8 0 0

JCR@2023

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ESI Highly Cited Papers on the List： 0 Unfold All

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30 Days PV： 1

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