Bioelectricity　performs　vital　functions　in　biological　organisms.　Piezoelectric　biomaterials　are　promising　candidates　for　tissue　repair　and　regeneration　because　they　can　simulate　natural　processes　in　biological　systems.　In　practical　applications,　however,　fabricating　piezoelectric　biomaterials　with　excellent　piezoelectricity,　favorable　tissue　adhesion,　and　full　biodegradability　are　challenging.　Herein,　a　bio-piezoelectric　dressing　is　developed　to　promote　wound　healing　and　monitor　human　activities　by　mimicking　endogenous　electric　field　and　mussel＇s　adhesion.　The　dressing　composed　of　self-powered　electrospun　poly(lactic　acid)　membrane　(PLA)　and　multifunctional　silk　fibroin　adhesive　matrix　(STG)　is　named　PLA/STG.　The　proposed　PLA　dressing　with　size　of　2　cm×　2　cm　could　provide　a　maximum　current　of　400　nA　and　a　voltage　of　10　V　under　20　N　force.　The　tissue　adhesion　strength,　time　for　self-healing,　antimicrobial　activity　and　biocompatibility　of　the　PLA/STG　reached　163.49　±　9.89　kPa,　2　min,　24　±　0.56　%　and　90　%,　respectively.　As　a　self-powered　dressing,　the　PLA/STG　can　promote　fibroblast　proliferation　and　migration　in　vitro,　as　well　as　facilitate　the　collagen　deposition,　angiogenesis,　and　re-epithelialization　in　vivo.　Furthermore,　additional　key　characteristics　of　hemostatic　and　sealing　performances　are　reported.　Overall,　the　bioinspired　dressing　displays　the　potential　applications　in　implantable　and　wearable　electrical　devices　for　wound　healing　and　real-time　monitoring　and　sensing.　©　2024　The　Authors