Covalent　organic　frameworks　(COFs)　have　been　regarded　as　promising　photocatalytic　materials.　However,　the　sluggish　diffusion　of　photoinduced　charges　in　a　single-component　COF　remains　the　obstacles　that　have　to　be　overcome.　Here,　we　demonstrate　a　synthesis　of　a　COF　bearing　dual　cocatalysts　Co3O4　and　Re　complex　as　photocatalyst　for　water　oxidation.　The　dual　cocatalysts　are　coordinated　on　the　COF,　and　enable　the　spatial　separation　of　photoinduced　charges.　The　generated　electrons　were　attracted　to　Re　moiety,　while　the　holes　were　localized　on　Co3O4　cocatalyst　for　water　oxidation　to　produce　O2　product.　The　synergy　of　dual　cocatalysts　of　COF　promote　the　charge　separation　and　redox　reaction.　Moreover,　hydroxyl　radicals　generated　from　the　hydration　of　COF　contribute　to　O−O　bond　formation,　which　is　the　key　step　of　O2　formation.　Accordingly,　an　excellent　O2　production　rate　of　400　μmol　g−1　h−1　under　visible　light　irradiation　was　obtained.　This　work　may　pave　the　way　to　the　development　of　highly　efficient　COF　photocatalysts　for　solar　energy　conversion.　©　2024　Wiley-VCH　GmbH.