The　widespread　utilization　of　noble　metal-based　catalysts　for　the　oxygen　evolution　reaction　(OER)　is　hindered　by　their　rarity　and　substantial　expense,　posing　significant　challenges　for　large-scale　applications.　Therefore,　developing　an　efficient　OER　electrocatalyst　for　proton　exchange　membrane　(PEM)　water　electrolyzers　remains　a　significant　challenge.　Here,　we　present　a　bottom-up　synthesis　strategy　utilizing　ultrasound-assisted　exfoliation　to　design　nickel-iron　bimetallic　organic　framework　(NiFe-MOF)　nanosheets　with　high　electrooxidation　activity,　in　situ　induced　by　carbon　quantum　dots　(CQDs).　This　approach　eliminates　the　reliance　on　intricate　and　inefficient　exfoliation　techniques,　producing　NiFe-MOF　nanosheets　with　a　regulated　thickness　of　just　10　nm.　This　enhanced　electron　transport　induced　by　CQDs　plays　a　pivotal　role　in　improving　the　OER　performance　of　NiFe-MOF,　achieving　a　current　density　of　10　mA　cm−2　with　an　overpotential　of　only　280　mV,　with　a　Tafel　slope　of　71.98　mV　dec−1,　lower　Rct,　and　larger　ECSA.　In　situ　FTIR　spectroscopy　suggests　that　the　OER　mechanism　in　NiFe-MOF-CQD　mainly　follows　the　adsorbate　evolution　mechanism.　The　NiFe-MOF-CQD　catalyst　demonstrates　remarkable　durability　and　resilience　during　PEM　water　electrolysis,　reaching　industrially　relevant　current　densities　of　2　A　cm−2　at　2　V.　This　research＇s　results　not　only　promote　green　and　low-carbon　development　but　also　inject　new　vitality　into　the　development　of　hydrogen　energy　technologies.　©　2024　The　Royal　Society　of　Chemistry.