Purpose:　To　investigate　the　associations　between　circulating　micronutrients　(vitamins　A,　C,　D,　E,　and　carotenoids)　and　the　risk　of　myopia.　Methods:　A　total　of　1,620　adolescents　from　the　2003–2006　National　Health　and　Nutrition　Examination　Survey　(NHANES)　were　included.　Logistic　regression　was　used　to　analyze　the　associations　of　micronutrients　with　myopia　and　high　myopia.　Restricted　cubic　spline　analysis　was　employed　to　assess　the　potential　nonlinear　relationships.　Results:　Among　the　1,620　adolescents,　549　were　diagnosed　with　myopia.　After　adjusting　for　multiple　covariates,　only　cis-β-carotene　was　significantly　associated　with　the　risk　of　myopia　(OR　1.19,　95%　CI　1.03–1.39)　and　high　myopia　(OR　1.44,　95%　CI　1.03–2.03).　No　significant　associations　were　found　between　vitamins　A,　D,　E,　C,　α-carotene,　trans-β-carotene,　lutein　zeaxanthin,　and　myopia.　No　nonlinear　relationships　were　observed　between　any　of　the　micronutrients　and　myopia.　Conclusion:　Cis-β-carotene　is　significantly　associated　with　an　increased　risk　of　myopia　and　high　myopia.　Further　research　is　needed　to　understand　the　underlying　mechanisms　and　potential　impact　of　cis-β-carotene　on　ocular　health.　Copyright　©　2024　Xiao,　Chen,　Lin,　Hu,　Liu,　Yusufu,　Huang　and　Li.