Background　and　Aims:　As　a　biomarker　of　insulin　resistance　(IR)　in　patients　with　acute　myocardial　infarction　(AMI),　the　triglyceride-glucose　index　(TyG　index)　has　received　significant　attention.　However,　most　research　on　AMI　has　focused　on　male　patients,　as　it　is　traditionally　believed　to　primarily　affect　males.　Therefore,　this　study　was　conducted　on　a　female　population　with　AMI　to　investigate　the　potential　correlation　between　the　TyG　index　and　their　outcomes.　Methods:　A　total　of　320　women　who　were　admitted　to　Fujian　Provincial　Hospital　for　AMI　between　January　2017　and　December　2019　were　included　in　this　study.　The　TyG　index　was　calculated　using　the　following　formula:　ln　[fasting　triglycerides　(TG)　(mg/dL)　×　fasting　plasma　glucose　(FPG)　(mg/dL)/2].　The　primary　endpoint　of　the　study　was　the　occurrence　of　major　adverse　cardiovascular　and　cerebrovascular　events　(MACCEs),　which　included　all-cause　mortality,　myocardial　infarction,　repeat　revascularization,　rehospitalization　for　heart　failure　and　stroke.　The　association　between　the　TyG　index　and　unfavorable　outcomes　in　female　patients　was　investigated　using　the　Cox　proportional　hazards　regression　model.　Results:　It　was　ultimately　estimated　that　111　patients　developed　MACCEs.　Females　with　high　TyG　indices　had　a　higher　prevalence　of　diabetes,　elevated　heart　rates,　and　hemoglobin　A1c,　as　well　as　a　higher　likelihood　of　undergoing　thrombus　aspiration　and　stent　placement.　The　TyG　index　was　found　to　be　positively　correlated　with　the　prevalence　of　hypertension,　diabetes,　low-density　lipoprotein　cholesterol,　hemoglobin　A1c,　and　damaged　vessels.　However,　this　correlation　was　modest,　yet　statistically　significant.　Furthermore,　after　adjusting　for　conventional　risk　factors,　the　TyG　index　(HR:　4.292,　95%　CI:　2.784–6.616,　p　＜　0.001)　was　independently　associated　with　MACCEs.　Conclusion:　As　an　independent　risk　predictor,　the　TyG　index　has　the　potential　to　enhance　clinical　outcomes　for　women　with　AMI.　©　2024　The　Author(s).　Health　Science　Reports　published　by　Wiley　Periodicals　LLC.