IntroductionThe　Arizona　Sexual　Experiences　Scale　(ASEX)　is　a　brief　questionnaire　that　evaluates　five　major　aspects　of　sexual　function:　sex　drive,　arousal,　erectile　function/vaginal　lubrication,　ability　to　reach　orgasm,　and　satisfaction　with　orgasm.　An　advantage　of　the　ASEX　is　its　simplicity　and　brevity　(five　items),　making　it　suitable　for　the　screening　of　sexual　function　problems　in　healthcare　contexts　and　large-scale　studies.　The　main　objective　of　this　study　was　to　examine　the　psychometric　properties　of　the　ASEX　in　a　multi-national　sample,　as　well　as　to　explore　sexual　function　according　to　countries,　genders,　and　sexual　orientations.MethodsThe　psychometric　examination　of　the　ASEX　was　conducted　with　a　sample　of　82,243　participants　(women　=　57.02%;　men　=　39.59%;　gender-diverse　=　3.38%;　Mage　=　32.39　years;　SD　=　12.52)　from　42　different　countries　speaking　26　languages.ResultsThe　CFA　supported　a　one-factor　solution.　Multigroup　CFAs　supported　configural,　metric,　partial　scalar,　and　residual　invariance　across　countries,　languages,　genders,　and　sexual　orientations.　Furthermore,　the　ASEX　showed　good　internal　consistency　(omega　=　.85)　and　convergent　validity　(e.g.,　significant　negative　associations　with　masturbation　and　sexual　intercourse　frequency).　Finally,　individuals　in　Eastern　countries,　women,　and　asexual　participants　reported　higher　levels　of　sexual　function　issues.Conclusions　and　Policy　ImplicationsThe　findings　supported　the　use　of　the　ASEX　as　a　tool　to　screen　for　sexual　function　problems　across　diverse　populations　in　multi-cultural　settings.　This　scale　may　be　used　to　improve　our　knowledge　on　the　cross-cultural　differences　on　the　expression　of　sexual　function,　serving　as　the　basis　for　the　development　of　culturally　tailored　interventions　for　the　improvement　of　this　basic　aspect　of　well-being.