The　valorization　of　lignocellulosic　biomass　represents　a　significant　frontier　in　scientific　research,　promising　a　sustainable　source　of　renewable　energy　and　valuable　chemical　compounds.　Traditional　methods　for　converting　lignocellulose　often　suffer　from　challenges　such　as　low　selectivity,　suboptimal　yield,　and　high　energy　consumption.　To　address　these　issues,　innovative　approaches　that　blend　different　catalytic　processes　are　gaining　traction.　One　such　approach　is　the　combination　of　sonication　with　photocatalysis　in　continuous-flow　systems.　This　method　offers　the　potential　to　revolutionize　lignocellulose　valorization　by　enhancing　process　efficiency　and　selectivity,　thus　opening　new　pathways　for　producing　high-value　chemicals　and　energy　sources.　This　paper　delves　into　the　potential　of　integrating　sonication　and　photocatalysis　for　lignocellulose　conversion　within　continuous-flow　systems.　It　discusses　the　opportunities　that　arise　from　this　synergistic　approach,　as　well　as　the　associated　challenges,　such　as　the　need　for　precise　control　of　reaction　conditions　and　the　integration　of　scalable　technologies.　Moreover,　a　critical　review　of　the　current　state　of　the　art　in　this　domain　is　provided　to　highlight　recent　advancements　and　identify　avenues　for　future　exploration.　This　paper　is　particularly　relevant　to　researchers,　engineers,　and　professionals　in　chemical　engineering,　renewable　energy,　and　environmental　science　who　are　focused　on　sustainable　technologies　and　biomass　conversion.　It　is　also　valuable　for　academic　and　industrial　stakeholders　seeking　innovative　solutions　to　enhance　the　efficiency　and　sustainability　of　biomass　processing.