Laccases　act　as　green　catalysts　for　oxidative　cross-coupling　of　phenolic　antioxidnt　compounds,　but　low　stability　and　non-recyclability　limit　its　application.　To　address　that,　metal-organic　frameworks　Cu-BTC　and　Cr-MOF　were　synthesized　as　supports　to　immobilize　the　efficient　laccase　from　Cerrena　sp.　HYB07.　The　Brunauer-Emmett-Teller　surface　area　of　Cu-BTC　and　Cr-MOF　were　1213.2　and　907.1　m2/g,　respectively.　The　two　carriers　respectively　presented　pore　diameters　of　1.2-10　nm　and　1.4-12　nm　as　octahedron,　indicating　nano-scale　mesoporosity.　These　Cu-BTC　and　Cr-MOF　carriers　could　adsorb　laccase　with　enzyme　loading　of　1933.2　and　1564.4　U/g　carrier,　respectively.　The　stability　and　organic　solvent　tolerance　of　Cu-BTC-laccase　and　Cr-MOF-laccase　were　both　obviously　improved　compared　to　free　laccase.　Thermal　inactivation　kinetics　showed　that　both　the　two　immobilized　laccases　displayed　lower　thermal　inactivation　rate　constants.　Importantly,　the　Cu-BTC-laccase　and　Cr-MOF-laccase　both　showed　much　higher　activity　for　cross-coupling　of　ethyl　ferulate　than　free　laccase,　which　had　2.5-fold　higher　cross-coupling　efficiency　than　that　by　free　laccase.　The　ethyl　ferulate　coupling　product　was　also　analyzed　by　mass　spectroscopy　and　the　synthesis　pathway　of　ethyl　ferulate　dimer　was　proposed.　The　cross　coupling　of　ethyl　ferulate　required　the　formation　of　radical　intermediates　of　ethyl　ferulate　generated　by　laccase　mediated　oxidation.　This　work　paved　the　way　for　MOFs　immobilized　laccase　for　cross　coupling　of　antioxidant　phenols.