This　study　explores　the　performance　of　asphalt　mixtures　modified　with　North　American　rock　asphalt　and　desulfurized　rubber　particles　at　varying　rubber-to-asphalt　ratios　ranging　from　18%　to　36%　by　weight.　A　comprehensive　set　of　laboratory　tests,　including　high-temperature　rutting　tests,　low-temperature　bending　tests,　indirect　tensile　tests,　and　freeze–thaw　splitting　tests,　were　conducted　to　evaluate　the　modified　mixtures.　The　results　indicate　that　both　wet　and　dry　blending　methods　produce　mixtures　that　meet　technical　requirements,　with　the　optimal　asphalt-to-aggregate　ratio　determined　to　be　7.1%.　At　a　rubber-to-asphalt　ratio　of　18%,　the　wet　blending　method　slightly　improves　high-temperature　rutting　resistance　compared　to　the　dry　method.　However,　an　increase　in　rubber　content　generally　enhances　rutting　resistance　regardless　of　the　blending　technique.　The　wet　blending　method　excels　in　low-temperature　crack　resistance,　possibly　due　to　better　rubber　dispersion,　while　an　increase　in　rubber　content　diminishes　crack　resistance　due　to　a　thinning　asphalt　film.　In　terms　of　fatigue　performance,　the　dry　blending　method　results　in　significantly　longer　fatigue　life,　with　a　27%　rubber-to-asphalt　ratio　exhibiting　optimal　balance.　The　dry　method　consistently　outperforms　the　wet　method　in　water　stability,　and　the　resistance　to　water　damage　increases　with　rubber　content.　In　conclusion,　this　study　provides　valuable　insights　into　optimizing　rubber-to-asphalt　ratios　and　blending　methods　for　various　application　needs,　showcasing　the　benefits　of　rock　asphalt　and　desulfurized　rubber　particles　in　asphalt　modification.　©　2024　by　the　authors.