The　application　of　2D　MXene　materials　in　the　biomedical　field　has　been　widely　explored.　Apart　from　excellent　photothermal　properties,　their　role　in　modulating　various　immune　cells　and　overcoming　immune-suppressive　tumor　microenvironments　is　waiting　to　be　discovered.　In　this　work,　a　novel　multifunctional　2D　vanadium　carbide　is　constructed　that　degrades　in　situ　in　the　tumor　microenvironment.　Various　characterizations　and　first-principles　calculations　indicated　that　V4C3　nanosheets　exhibit　excellent　light　absorption　and　photothermal　conversion　capabilities　in　the　NIR-II　biological　window.　The　photothermal　and　X-ray　absorption　properties　of　V4C3　nanosheets　enabled　dual-modal　photoacoustic　imaging/computerized　tomography　(PA/CT)　imaging　functionality.　The　V4C3　nanosheets　in　the　tumor　microenvironment　decomposed　under　the　effect　of　H2O2　and　GSH,　triggering　a　Fenton-like　reaction.　The　photothermal　ablation　and　reactive　oxygen　species　(ROS)　generation　capabilities　enabled　V4C3　nanosheets　to　convert　cold　tumors　into　hot　ones　(macrophage:　M2　-＞　M1)　and　induce　reactions　like　immunogenic　cell　death　(ICD).　Dendritic　cell　(DC)　cells　matured　under　the　ICD　stimulation,　which　promoted　T　cell　activation,　reduced　Treg　cells　and　thus　effectively　enhanced　tumor　immunotherapy.　The　multiple　properties　including　imaging,　photothermal,　enzyme-driven,　and　immune　functions　enable　V4C3　nanosheets　to　ablate　tumors　effectively.　This　study　provides　an　example　for　the　research　of　the　multifunctional　exploration　and　application　of　MXene　in　biomedicine　filed.　The　novel　multifunctional　2D　vanadium　carbide　(V4C3)　MXene　nanosheets　in　question　can　be　degraded　in　situ　in　the　tumor　microenvironment,　which　show　superior　photothermal　tumor　ablation　ability　in　the　NIR-II　biological　window.　Its　ability　to　trigger　ICD　reaction　can　significantly　enhance　tumor　immunotherapy.　image