In　this　work,　we　synthesized　a　novel　β-cyclodextrin/poly(2-acrylamide-2-methylpropionic　acid)/attapulgite　(CAMA)　hydrogel　for　uranium(VI)　adsorption.　Various　instrumental　techniques　such　as　FTIR,　SEM,　EDX,　and　TGA　were　utilized　for　characterization　of　the　CAMA.　Simultaneously,　different　important　parameters,　in　specific　pH,　time,　initial　uranyl　ion　concentration　and　temperature　were　investigated　to　evaluate　the　optimal　conditions　of　the　adsorption　process.　The　experiments　proofs　that　the　adsorption　follows　the　pseudo-second-order　kinetic　model　so　as　the　Langmuir　model,　and　revealed　the　maximum　adsorption　capacity　of　434.78 mg g−1　at　298.15 K.　Regeneration　studies　further　sighted　out　the　good　reusability　of　the　synthesized　CAMA　hydrogel.　©　2023,　Akadémiai　Kiadó,　Budapest,　Hungary.