Green Late-Stage Functionalization of Tryptamines - Details

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Abstract：

An　efficient　and　rapid　protocol　for　the　oxidative　halogenation　of　tryptamines　with　10　%　aqueous　NaClO　has　been　developed.　This　reaction　is　featured　by　its　operational　simplicity,　metal-free　conditions,　no　purification,　and　high　yield.　Notably,　the　resulting　key　intermediates　are　suitable　for　further　functionalization　with　various　nucleophiles,　including　amines,　N-aromatic　heterocycles,　indoles　and　phenols.　The　overall　transformation　exhibits　broad　functional-group　tolerance　and　is　applicable　to　the　late-stage　functionalization　of　complex　biorelevant　molecules.　©　2024　Wiley-VCH　GmbH.

Keyword：

Amines Cell death Chlorine compounds Sodium compounds Sustainable chemistry

Community：

[ 1 ] [Xu, Jiayi]Key Laboratory of Molecule Synthesis and Function Discovery, College of Chemistry, Fuzhou University, Fuzhou; 350108, China
[ 2 ] [Zhang, Yahui]Key Laboratory of Molecule Synthesis and Function Discovery, College of Chemistry, Fuzhou University, Fuzhou; 350108, China
[ 3 ] [Cai, Qiling]Fujian Provincial Key Laboratory of Medical Instrument and Pharmaceutical Technology, College of Biological Science and Technology, Fuzhou University, Fuzhou; 350108, China
[ 4 ] [Chen, Li]Fujian Provincial Key Laboratory of Medical Instrument and Pharmaceutical Technology, College of Biological Science and Technology, Fuzhou University, Fuzhou; 350108, China
[ 5 ] [Sun, Yang]School of Basic Medical Sciences, Fujian Medical University, Fuzhou; 350122, China
[ 6 ] [Liu, Qinying]School of Basic Medical Sciences, Fujian Medical University, Fuzhou; 350122, China
[ 7 ] [Gao, Yu]Key Laboratory of Molecule Synthesis and Function Discovery, College of Chemistry, Fuzhou University, Fuzhou; 350108, China
[ 8 ] [Chen, Haijun]Key Laboratory of Molecule Synthesis and Function Discovery, College of Chemistry, Fuzhou University, Fuzhou; 350108, China