The　development　of　innovative　multi-emission　sensors　for　the　rapid　and　accurate　detection　of　contaminants　is　both　vital　and　challenging.　In　this　study,　utilizing　two　rigid　ligands　(H3ICA　and　H4BTEC),　a　series　of　water-stable　bimetallic　organic　frameworks　(EuTb-MOFs)　were　synthesized.　Luminescent　investigations　have　revealed　that　EuTb-MOF-1　exhibits　prominent　multiple　emission　peaks,　attributed　to　the　distinctive　fluorescence　characteristics　of　Eu(III)　and　Tb(III)　ions.　Therefore,　EuTb-MOF-1　efficiently　recognized　various　metal　ions　and　pharmaceutical　compounds　through　2D　decoded　maps.　Fe3+　and　Pb2+　exhibited　significant　quenching　effects　on　the　luminescence　of　EuTb-MOF-1,　which　were　attributed　to　the　internal　filtering　effect　and　the　interaction　between　Lewis　basic　sites　within　EuTb-MOF-1　and　Pb2+　ions,　respectively.　Furthermore,　EuTb-MOF-1　demonstrated　high　sensitivity　to　sulfonamide　antibiotics,　with　detection　limits　of　0.037　μM　for　SMZ　and　0.041　μM　for　SDZ,　respectively.　In　addition,　EuTb-MOF-1　was　immobilized　to　prepare　MOF-based　test　strips,　enabling　direct　visual　detection　of　sulfonamides　as　a　portable　sensor.　With　excellent　water　stability,　multi-responsive　recognition　capabilities,　and　high　sensitivity　to　specific　analytes,　EuTb-MOF-1　is　a　promising　candidate　for　environmental　contaminant　detection　in　aquatic　systems.　©　2024