Objective:　To　evaluate　the　effectiveness　of　monitoring　and　managing　process　quality　control　indicators　in　the　prevention　of　constipation　among　hospitalized　patients　with　acute　coronary　syndrome　(ACS).　Methods:　A　total　of　512　hospitalized　patients　diagnosed　with　ACS　between　January　and　June　2022　were　screened　for　inclusion　in　the　study.　Ultimately,　456　eligible　participants　were　enrolled　and　divided　into　two　groups　based　on　the　chronological　order　of　admission:　the　control　group　and　the　observation　group.　Upon　admission,　both　groups　of　patients　received　routine　constipation　prevention　measures　in　the　department.　However,　the　observation　group　was　subjected　to　targeted　process　quality　control　management,　which　included　monitoring　and　managing　five　indicators　related　to　constipation　prevention:　correctness　of　bowel　movement　recording;　usage　rate　of　laxatives;　execution　rate　of　physical　interventions;　implementation　rate　of　constipation　prevention　education;　completion　rate　of　dietary　structure　and　habit　assessments.　Data　were　analyzed　using　SPSS,　with　t　tests　and　χ2　tests　for　group　comparisons.　Results:　In　comparison　to　the　control　group,　the　observation　group　demonstrated　significant　advantages　in　terms　of　constipation　incidence,　completion　rates　of　the　five　process　quality　control　indicators,　occurrence　rates　of　adverse　cardiac　events　during　defecation,　and　PHQ-9　scores　before　discharge.　These　disparities　demonstrated　statistical　significance　with　a　p　value　＜　0.05.　Conclusion:　Target-oriented　process　quality　control　management　is　shown　to　be　effective　in　reducing　constipation　incidence　and　adverse　cardiac　events　during　constipation　episodes,　as　well　as　alleviating　depressive　symptoms　among　ACS　patients,　thus　providing　a　safe　and　effective　approach　to　constipation　prevention.　©　2024　The　Author(s).　Health　Science　Reports　published　by　Wiley　Periodicals　LLC.