Multifunctional Biomimetic Nanocarriers for Dual-Targeted Immuno-Gene Therapy Against Hepatocellular Carcinoma - Details

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Abstract：

Growing　evidences　have　proved　that　tumors　evade　recognition　and　attack　by　the　immune　system　through　immune　escape　mechanisms,　and　PDL1/Pbrm1　genes　have　a　strong　correlation　with　poor　response　or　resistance　to　immune　checkpoint　blockade　(ICB)　therapy.　Herein,　a　multifunctional　biomimetic　nanocarrier　(siRNA-CaP@PD1-NVs)　is　developed,　which　can　not　only　enhance　the　cytotoxic　activity　of　immune　cells　by　blocking　PD1/PDL1　axis,　but　also　reduce　tumor　immune　escape　via　Pbrm1/PDL1　gene　silencing,　leading　to　a　significant　improvement　in　tumor　immunosuppressive　microenvironment.　Consequently,　the　nanocarrier　promotes　DC　cell　maturation,　enhances　the　infiltration　and　activity　of　CD8+　T　cells,　and　forms　long-term　immune　memory,　which　can　effectively　inhibit　tumor　growth　or　even　eliminate　tumors,　and　prevent　tumor　recurrence　and　metastasis.　Overall,　this　study　presents　a　powerful　strategy　for　co-delivery　of　siRNA　drugs,　immune　adjuvant,　and　immune　checkpoint　inhibitors,　and　holds　great　promise　for　improving　the　effectiveness　and　safety　of　current　immunotherapy　regimens.　©　2024　The　Author(s).　Advanced　Science　published　by　Wiley-VCH　GmbH.

Keyword：

immune checkpoint blockade immuno-gene therapy immuno-sensitization multifunctional biomimetic nanocarrier PDL1/Pbrm1 gene

Community：

[ 1 ] [Sun Y.]The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou, 350025, China
[ 2 ] [Sun Y.]Mengchao Med-X Center, Fuzhou University, Fuzhou, 350116, China
[ 3 ] [Liu Y.]The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou, 350025, China
[ 4 ] [Liu Y.]College of Biological Science and Engineering, Fuzhou University, Fuzhou, 350116, China
[ 5 ] [Li R.]The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou, 350025, China
[ 6 ] [Li R.]College of Biological Science and Engineering, Fuzhou University, Fuzhou, 350116, China
[ 7 ] [Zhang C.]The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou, 350025, China
[ 8 ] [Zhang C.]Mengchao Med-X Center, Fuzhou University, Fuzhou, 350116, China
[ 9 ] [Wu M.]The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou, 350025, China
[ 10 ] [Wu M.]Mengchao Med-X Center, Fuzhou University, Fuzhou, 350116, China
[ 11 ] [Zhang X.]The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou, 350025, China
[ 12 ] [Zhang X.]Mengchao Med-X Center, Fuzhou University, Fuzhou, 350116, China
[ 13 ] [Zheng A.]The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou, 350025, China
[ 14 ] [Zheng A.]Mengchao Med-X Center, Fuzhou University, Fuzhou, 350116, China
[ 15 ] [Liao N.]The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou, 350025, China
[ 16 ] [Zheng Y.]The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou, 350025, China
[ 17 ] [Xu H.]The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou, 350025, China
[ 18 ] [Zeng R.]The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou, 350025, China
[ 19 ] [Zeng R.]Mengchao Med-X Center, Fuzhou University, Fuzhou, 350116, China
[ 20 ] [Zeng Y.]The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou, 350025, China
[ 21 ] [Zeng Y.]Mengchao Med-X Center, Fuzhou University, Fuzhou, 350116, China
[ 22 ] [Zeng Y.]Liver Disease Center, The First Affiliated Hospital of Fujian Medical University, Fuzhou, 350005, China
[ 23 ] [Liu X.]The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou, 350025, China
[ 24 ] [Liu X.]Mengchao Med-X Center, Fuzhou University, Fuzhou, 350116, China
[ 25 ] [Liu X.]CAS Key Laboratory of Design and Assembly of Functional Nanostructures, Fujian Institute of Research on the Structure of Matter Chinese Academy of Sciences, Fuzhou, 350002, China

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Related Keywords：

Multifunctional Biomimetic Nanocarriers for Dual-Targeted Immuno-Gene Therapy Against Hepatocellular Carcinoma
2024，ADVANCED SCIENCE
Highly Efficient Bifunctional Peptides for Tumor Immunotherapy by Simultaneously Activating T Cells and Blocking PD-L1 Immune Checkpoint
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Source ：

Advanced Science

ISSN： 2198-3844

Year： 2024

Issue： 34

Volume： 11

1 4 . 3 0 0

JCR@2023

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ESI Highly Cited Papers on the List： 0 Unfold All

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