Thousands　of　chemicals　have　been　released　into　the　environment　in　recent　decades.　The　presence　of　emerging　contaminants　(ECs)　in　water　has　emerged　as　a　pressing　concern.　Adsorption　is　a　viable　solution　for　the　removal　of　ECs.　Metal-organic　frameworks　(MOFs)　have　shown　great　potential　as　efficient　adsorbents,　but　their　dispersed　powder　form　limits　their　practical　applications.　Recently,　researchers　have　developed　various　separable　MOF-based　adsorbents　to　improve　their　recyclability.　The　purpose　of　this　review　is　to　summarize　the　latest　developments　in　the　construction　of　separable　MOF-based　adsorbents　and　their　applications　in　adsorbing　ECs.　The　construction　strategies　for　separable　MOFs　are　classified　into　four　categories:　magnetic　MOFs,　MOF-fiber　composites,　MOF　gels,　and　binder-assisted　shaping.　Typical　emerging　contaminants　include　pesticides,　pharmaceuticals　and　personal　care　products,　and　endocrine-disrupting　compounds.　The　adsorption　performance　of　different　materials　is　evaluated　based　on　the　results　of　static　and　dynamic　adsorption　experiments.　Additionally,　the　regeneration　methods　of　MOF-based　adsorbents　are　discussed　in　detail　to　facilitate　effective　recycling　and　reuse.　Finally,　challenges　and　potential　future　research　opportunities　are　proposed,　including　reducing　performance　losses　during　the　shaping　process,　developing　assessment　systems　based　on　dynamic　purification　and　real　polluted　water,　optimizing　regeneration　methods,　designing　multifunctional　MOFs,　and　low-cost,　large-scale　synthesis　of　MOFs.　©　2024　American　Chemical　Society.