Bacterial　infections　are　a　major　public　health　challenge　around　the　world.　The　development　of　novel　surface　coatings　that　effectively　inhibit　bacterial　adhesion,　proliferation　and　growth　is　a　critical　step　in　addressing　this　global　challenge.　Photocatalytic　antibacterial　therapy　has　proven　to　be　an　effective　approach　and　has　received　increasing　attention.　However,　it　is　still　a　challenge　to　obtain　coatings　with　both　antibacterial　adhesion　and　durable　photocatalytic　antibacterial　functions.　Herein,　an　acridine-based　coating　with　antibacterial　adhesion　and　photocatalytic　antibacterial　properties　was　prepared　by　simple　methods　(i.e.,　spin-coating,　spray-coating,　and　drop-coating)　and　can　be　applied　to　various　substrates.　The　bacterial　anti-adhesion　test　results　showed　that　the　coating　could　effectively　prevents　the　adhesion　of　Escherichia　coli　(E.　coli),　Staphylococcus　aureus　(S.　aureus),　and　Pseudomonas　aeruginosa　(P.　aeruginosa),　indicating　the　strong　anti-fouling　capability.　The　acridine-based　coating　demonstrated　durable　photocatalytic　antimicrobial　activity,　remaining　99.3　%　antibacterial　effective　against　all　three　bacterial　strains　even　after　30　days　exposed　to　visible　light.　The　coating　can　significantly　reduce　or　eliminate　the　risk　of　contamination　and　cross-contamination,　making　it　ideal　for　use　in　public　healthcare　environments.　©　2024