Wound　dressings　play　a　critical　role　in　the　wound　healing　process;　however,　conventional　dressings　often　address　singular　functions,　lacking　versatility　in　meeting　diverse　wound　healing　requirements.　Herein,　dual-network,　multifunctional　hydrogels　(PSA/CS-GA)　have　been　designed　and　synthesized　through　a　one-pot　approach.　The　in　vitro　and　in　vivo　experiments　demonstrate　that　the　optimized　hydrogels　have　exceptional　antifouling　properties,　potent　antibacterial　effects　and　rapid　hemostatic　capabilities.　Notably,　in　a　full-thickness　rat　wound　model,　the　hydrogel　group　displays　a　remarkable　wound　healing　rate　exceeding　95%　on　day　10,　surpassing　both　the　control　group　and　the　commercial　3M　group.　Furthermore,　the　hydrogels　exert　an　anti-inflammatory　effect　by　reducing　inflammatory　factors　interleukin　6　(IL-6)　and　tumor　necrosis　factor-α　(TNF-α),　enhance　the　release　of　the　vascular　endothelial　growth　factor　(VEGF)　to　promote　blood　vessel　proliferation,　and　augment　collagen　deposition　in　the　wound,　thus　effectively　accelerating　wound　healing　in　vivo.　These　innovative　hydrogels　present　a　novel　and　highly　effective　approach　to　wound　healing.　©　2024　The　Royal　Society　of　Chemistry.