Hydrogel-based　wearable　sensing　devices　are　attractive　and　have　broad　application　prospects　on　motion　intention　recognition　and　health　monitoring.　The　research　on　the　aspect　of　their　wearable　comfort　and　the　improvement　of　breathability　is　essential.　In　this　paper,　a　breathable　porous　hydrogel　film　was　prepared　using　a　template　method　combined　with　the　inverse　Hofmeister　effect.　Different　from　conventional　hydrogels　that　utilize　the　Hofmeister　effect　by　using　lyophilic　ions　for　toughening,　our　approach　involved　the　reverse　application　of　the　Hofmeister　effect,　the　use　of　chaotropic　ions,　which　induced　a　loosening　effect　within　the　hydrogel　interior,　thereby　achieving　a　more　uniform　pore　distribution.　The　prepared　hydrogel　film　has　excellent　mechanical　properties　(elongation　at　break　of　404%,　tensile　strength　of　173　kPa),　air　permeability　(9.96　mg·cm-2·h-1),　and　sensitivity　(GF　=　4.41).　The　film　is　used　as　a　wearable　sensor　with　high　sensitivity　and　accuracy　to　monitor　human　finger,　wrist,　and　large　joint　movements,　human　electrophysiological　signals　[electromyogram　(EMG)　and　electrocardiogram　(ECG)],　small　changes　in　vocal　cord　vibration,　and　manipulation　of　electronic　devices　for　gaming.　This　work　provides　an　approach　for　the　preparation　of　breathable　hydrogel　films　as　wearable　sensors.　©　2024　American　Chemical　Society.