The　deployment　of　Li-S　batteries　in　the　commercial　sector　faces　obstacles　due　to　their　low　electrical　conductivity,　slow　redox　reactions,　quick　fading　of　capacity,　and　reduced　coulombic　efficiency.　These　issues　stem　from　the　＂shuttle　effect＂　associated　with　lithium　polysulfides　(LiPSs).　In　this　work,　a　haystack-like　CeO2　derived　from　a　cerium-based　metal-organic　framework　(Ce-MOF)　is　obtained　for　the　modification　of　a　polypropylene　separator.　The　carbon　framework　and　CeO2　coexist　in　this　haystack-like　structure　and　contribute　to　a　synergistic　effect　on　the　restriction　of　LiPSs　shuttling.　The　carbon　network　enhances　electron　transfer　in　the　conversion　of　LiPSs,　improving　the　rate　performance　of　the　battery.　Moreover,　CeO2　enhances　the　redox　kinetics　of　LiPSs,　effectively　reducing　the　＂shuttle　effect＂　in　Li-S　batteries.　The　Li-S　battery　with　the　optimized　CeO2　modified　separator　shows　an　initial　discharge　capacity　of　870.7　mAh/g　at　2　C,　maintaining　excellent　capacity　over　500　cycles.　This　research　offers　insights　into　designing　functional　separators　to　mitigate　the　＂shuttle　effect＂　in　Li-S　batteries.