Continuous-flow　microfluidic　biochips　(CFMBs)　can　precisely　manipulate　microfluids　for　bioassays.　In　order　to　enhance　the　efficiency　of　bioassays,　it　is　imperative　to　carefully　consider　operation　scheduling　and　device　binding　schemes.　The　existing　work　has　considered　device　volume　constraints　at　high-level　synthesis　to　meet　the　actual　fluid　transport　requirements　of　the　CFMBs.　However,　this　work　is　based　on　integer　linear　programming,　which　has　a　high　algorithmic　complexity　and　makes　it　difficult　to　meet　the　large-scale　integration　requirements　of　CFMBs.　Therefore,　a　fast　high-level　synthesis　algorithm　based　on　a　discrete　particle　swarm　algorithm　under　device　volume　constraint　is　proposed.　We　propose　a　particle　encoding　scheme　based　on　the　operation　priorities　and　the　device　binding　scheme.　In　addition,　the　corresponding　particle　initialization　method　and　update　strategy　are　proposed　to　satisfy　the　device　volume　constraint.　The　experimental　results　show　that　the　proposed　algorithm　can　obtain　high-level　synthesis　results　in　a　short　time.　©　2023　IEEE.