Information　encryption　is　an　important　means　to　improve　the　security　of　anti-counterfeiting　labels.　At　present,　it　is　still　challenging　to　realize　an　anti-counterfeiting　label　with　multi-function,　high　security　factor,　low　production　cost,　and　easy　detection　and　identification.　Herein,　using　inkjet　and　screen　printing　technology,　we　construct　a　multi-dimensional　and　multi-level　dynamic　optical　anti-counterfeiting　label　based　on　instantaneously　luminescent　quantum　dots　and　long　afterglow　phosphor,　whose　color　and　luminous　intensity　varied　in　response　to　time.　Self-assembled　quantum　dot　patterns　with　intrinsic　fingerprint　information　endow　the　label　with　physical　unclonable　functions　(PUFs),　and　the　information　encryption　level　of　the　label　is　significantly　improved　in　view　of　the　information　variation　in　the　temporal　dimension.　Furthermore,　the　convolutional　residual　neural　networks　are　used　to　decode　the　massive　information　of　PUFs,　enabling　fast　and　accurate　identification　of　the　anti-counterfeit　labels.　©　2022　American　Chemical　Society.