1,1-Oxycarbonation of Terminal Alkynes via Sequential Borylation, 1,2-Migration, and Oxidation with Oxone - Details

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Alkynes　are　readily　available　and　multifunctional　synthetic　intermediates,　but　their　1,1-oxofunctionalization　remains　challenging.　Herein,　we　report　a　1,1-oxycarbonation　of　terminal　alkynes　to　construct　ketones　through　sequential　borylation,　1,2-carbon　migration,　and　oxidation　with　Oxone　as　the　proton　source　and　oxidant.　The　synthetic　potential　of　this　transformation　is　showcased　by　the　broad　functional　groups,　scale-up　synthesis,　and　diverse　product　transformations.　©　2024　American　Chemical　Society.

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[ 1 ] [Zhang G.]Key Laboratory of Molecule Synthesis and Function Discovery, Fujian Province University, College of Chemistry at Fuzhou University, Fujian, Fuzhou, 350108, China
[ 2 ] [Feng B.]Key Laboratory of Molecule Synthesis and Function Discovery, Fujian Province University, College of Chemistry at Fuzhou University, Fujian, Fuzhou, 350108, China
[ 3 ] [Wang Y.]College of Materials Science and Engineering, Fuzhou University, Fujian, Fuzhou, 350108, China
[ 4 ] [Chen J.]College of Materials Science and Engineering, Fuzhou University, Fujian, Fuzhou, 350108, China
[ 5 ] [Ma X.]Key Laboratory of Molecule Synthesis and Function Discovery, Fujian Province University, College of Chemistry at Fuzhou University, Fujian, Fuzhou, 350108, China
[ 6 ] [Song Q.]Key Laboratory of Molecule Synthesis and Function Discovery, Fujian Province University, College of Chemistry at Fuzhou University, Fujian, Fuzhou, 350108, China
[ 7 ] [Song Q.]School of Chemistry and Chemical Engineering, Henan Normal University, Henan, Xinxiang, 453007, China

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Organic Letters

ISSN： 1523-7060

Year： 2024

Issue： 15

Volume： 26

Page： 3109-3113

4 . 9 0 0

JCR@2023

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SCOPUS Cited Count： 2

ESI Highly Cited Papers on the List： 0 Unfold All

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