Photothermal　therapy　(PTT)　has　attracted　extensive　attention　in　cancer　treatment　because　of　its　advantages　of　non-invasive　and　few　side　effects.　Gold　nanoparticles　and　boron-fluorine-dipyrrole　(BODIPY)　dye　have　been　used　as　photothermal　agents　(PTAs),　but　they　have　problems　such　as　easy　aggregation,　poor　water　solubility　and　low　photothermal　conversion　efficiency.　In　this　work,　we　used　conventional　liposomes　for　in　situ　generation　of　small　gold　nanoparticles　and　sequentially　loading　BODIPY　to　overcome　the　drawbacks　of　the　two　PTAs　and　simultaneously　realize　enhanced　PTT.　Gold-　and　BODIPY-coordinated　liposomal　nanocomplexes　LAB　with　small　gold　nanoparticles　adsorbed　on　the　surface　and　BODIPY　entrapped　inside　showed　uniform　size　of　about　100　nm　with　good　stability.　LAB　demonstrated　laser-responsive　drug　release　property,　good　cellular　uptake　efficiency　and　tumor　accumulation　ability.　After　laser　irradiation,　LAB　can　exert　enhanced　PTT　in　cancer　cell　lines　by　reducing　mitochondrial　membrane　potential　and　increase　intracellular　reactive　oxygen　species　level　to　promote　cell　apoptosis.　In　tumor-bearing　mice,　LAB　showed　fantastic　tumor　inhibition　effect　with　good　biosafety.　This　work　provides　a　convenient　method　to　develop　PTA　combinations　for　enhanced　PTT,　which　could　lay　the　foundation　for　the　green　construction　of　new　PTAs　for　PTT　by　employing　clinically　used　formulations　and　PTAs.　©　2024　The　Authors